Background: : The results of previous studies indicated that the addition of surfactant to the base fluid affects considerably the behavior of the solution. As a result, it is important to focus on the effects of surfactant on the pressure drop and heat transfer within the mini-channel. Methods: : In this experimental study, the effects of Tween 80 and SDS surfactants on the pressure drop and heat transfer in the mini-channel are investigated. The effects of Reynolds number and volume fraction of surfactants are studied. Findings: : The results show that the pressure drop boosts as the volume fraction of Tween 80 surfactant is increased. With boosting the volume fraction of Tween 80 surfactant, the Nusselt number is increased and the maximum Nusselt number can be observed for the highest values of Reynolds number and volume fraction. For the water/Tween 80 solution, in most operating conditions and volume fractions, the performance evaluation criterion has the value larger than unity. It is also observed that with using the SDS surfactant, the friction factor decreases. For this surfactant, with boosting the Reynolds number, the drag reduction parameter decreases and reaches the lowest value at the Reynolds number in the range of 5000 to 5500. © 2021 Taiwan Institute of Chemical Engineers