Immunostimulatory Effect of Moringa oleifera Extracts on Cyclophosphamide-induced Immunosuppressed Mice

被引：1

作者：

Pham, Anh Thi Van ^{[1
]}

Luong, Minh Hien ^{[2
]}

Dinh, Hang Thi Thu ^{[1
]}

Mai, Thanh Phuong ^{[1
]}

Trinh, Quang Vinh ^{[1
]}

Luong, Long Hoang ^{[3
,4
]}

机构：

[1] Hanoi Med Univ, Dept Pharmacol, Hanoi, Vietnam

[2] Univ Sci & Technol Hanoi, Dept Life Sci, Hanoi, Vietnam

[3] Hanoi Med Univ, Ctr Gene & Prot Res, 1 Ton That Tung St, Hanoi 10000, Vietnam

[4] Natl E Hosp, Dept Allergy Immunol & Dermatol, Hanoi, Vietnam

来源：

JOURNAL OF HERBS SPICES AND MEDICINAL PLANTS | 2021年 / 27卷 / 04期

关键词：

Bioactivity; immunostimulatory activity; immunosuppression; Swiss mice;

D O I：

10.1080/10496475.2021.1934620

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

In this study, the effect of Moringa oleifera extracts were investigated on an immunosuppressed model of cyclophosphamide-induced Swiss mice. M. oleifera seed and root extracts (2.0 g kg(-1) body wt) were administered orally for 7 consecutive days; cyclophosphamide (CP) (200 mg kg(-1) i.p.) was administered by IV on the 4(th) day. Results indicated that the extracts of the M. oleifera seeds and roots ameliorated the immunosuppressive effects of CP on delayed type hypersensitivity (DTH) response, leukocyte counts, relative organ weight, IgM concentration, serum TNF-alpha assay and micro-histological images. This study demonstrated in vivo the therapeutic effect of M. oleifera on the immune response in clinical application.

引用

页码：377 / 385

页数：9

共 50 条

[41] Immunomodulatory effects of selenium-enriched peptides from soybean in cyclophosphamide-induced immunosuppressed mice
Zhang, Jian
Gao, Siwei
Li, He
Cao, Mengdi
Li, Wenhui
Liu, Xinqi
FOOD SCIENCE & NUTRITION, 2021, 9 (11): : 6322 - 6334
[42] Ginger polysaccharides enhance intestinal immunity by modulating gut microbiota in cyclophosphamide-induced immunosuppressed mice
Liu, Jun -ping
Wang, Jie
Zhou, Si-xuan
Huang, De-chun
Qi, Guo-hong
Chen, Gui-tang
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 2022, 223 : 1308 - 1319
[43] Immunomodulatory and antioxidant effects of hydroxytyrosol in cyclophosphamide-induced immunosuppressed broilers
Shan, Chunlan
Miao, Fujun
POULTRY SCIENCE, 2022, 101 (01)
[44] Ovario- protective effect of Moringa oleifera leaf extract against cyclophosphamide-induced oxidative ovarian damage and reproductive dysfunction in female rats
Soliman, Seham Samir
Suliman, Ahmed A.
Fathy, Khaled
Sedik, Ahmed A.
SCIENTIFIC REPORTS, 2025, 15 (01):
[45] Uroprotective effect of pantoprazole against cyclophosphamide-induced cystitis in mice
Seckin Engin
Elif Nur Barut
Burak Barut
Mine Kadioglu Duman
Cansu Kaya
Gokcen Kerimoglu
Arzu Ozel
Supportive Care in Cancer, 2019, 27 : 4273 - 4281
[46] Inhibitory effect of carboxymethylpachymaran on cyclophosphamide-induced oxidative stress in mice
Wei, Xiao-Jie
Hu, Ting-Jun
Chen, Jiong-Ran
Wei, Ying-Yi
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 2011, 49 (04) : 801 - 805
[47] Ameliorative effect of metformin on cyclophosphamide-induced memory impairment in mice
Alhowail, A. H.
Chigurupati, S.
Sajid, S.
Mani, V.
EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES, 2019, 23 (21) : 9660 - 9666
[48] Uroprotective effect of pantoprazole against cyclophosphamide-induced cystitis in mice
Engin, Seckin
Barut, Elif Nur
Barut, Burak
Duman, Mine Kadioglu
Kaya, Cansu
Kerimoglu, Gokcen
Ozel, Arzu
SUPPORTIVE CARE IN CANCER, 2019, 27 (11) : 4273 - 4281
[49] EFFECT OF CYCLOPHOSPHAMIDE-INDUCED SUPPRESSOR CELLS ON AUTOIMMUNITY IN NZB MICE
GREELEY, EH
SEGRE, M
SEGRE, D
FEDERATION PROCEEDINGS, 1983, 42 (05) : 1206 - 1206
[50] Immunomodulatory effect of Schisandra polysaccharides in cyclophosphamide-induced immunocompromised mice
Yu, Jiahui
Cong, Lixin
Wang, Chunmei
Li, He
Zhang, Chengyi
Guan, Xingang
Liu, Peng
Xie, Yu
Chen, Jianguang
Sun, Jinghui
EXPERIMENTAL AND THERAPEUTIC MEDICINE, 2018, 15 (06) : 4755 - 4762

← 1 2 3 4 5 →