Prevalence of antibiotic resistance of Staphylococcus aureus in cystic fibrosis infection: a systematic review and meta-analysis

被引：4

作者：

Xu, Xuemei ^{[1
]}

Zhang, Xiang ^{[2
]}

Zhang, Guoying ^{[3
,4
]}

Tad, Danyal Abbasi ^{[5
]}

机构：

[1] Wenzhou Hosp Integrated Tradit Chinese & Western M, Pharm Dept, Wenzhou, Peoples R China

[2] Fifth Hosp Ruian, Lab Dept, Ruian, Peoples R China

[3] Wenzhou Med Univ, Ruian Peoples Hosp, Ruian, Peoples R China

[4] Wenzhou Med Univ, Hosp 3, Ruian, Peoples R China

[5] Azad Univ Shahr E Kord, Vet Dept, Shahrekord, Iran

来源：

JOURNAL OF GLOBAL ANTIMICROBIAL RESISTANCE | 2024年 / 36卷

关键词：

Staphylococcus aureus; Antibiotic resistance; Cystic fibrosis; Meta analysis; Vancomycin; ANTIMICROBIAL SUSCEPTIBILITY; MOLECULAR EPIDEMIOLOGY; MRSA; ERADICATION;

D O I：

10.1016/j.jgar.2023.05.006

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

Objectives: Cystic fibrosis (CF) is a hereditary recessive disease that affects the mucous clearance of the lungs and allows bacteria such as Staphylococcus aureus to settle in the lung and cause infection. This study examined the prevalence of antibiotic resistance of S. aureus in cystic fibrosis infection using a systematic review and meta-analysis. Methods: A comprehensive and systematic search of related articles was conducted through the PubMed, Scopus, and Web of Science databases until March 2022. The weighted pooled resistance rate of antibiotics was analysed with Freeman-Tukey double arcsine transformation in the Stata software version 17.1 using the Metaprop command. Results: In this meta-analysis, 25 studies were used based on criteria to evaluate the pattern of S. aureus resistance in CF. Vancomycin and teicoplanin were the most effective options for treatment of CF patients; the highest level of antibiotic resistance observed was to erythromycin and clindamycin. Conclusion: High levels of resistance to most of the antibiotics studied was observed. The high levels of antibiotic resistance observed are worrisome and indicate the need to monitor antibiotic use. (c) 2023 The Authors. Published by Elsevier Ltd on behalf of International Society for Antimicrobial Chemotherapy. This is an open access article under the CC BY license ( http://creativecommons.org/licenses/by/4.0/ )

引用

页码：419 / 425

页数：7

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