The complex interplay of tumor-infiltrating cells in driving therapeutic resistance pathways

被引：12

作者：

Li, Dengxiong ^{[1
]}

Shao, Fanglin ^{[2
]}

Yu, Qingxin ^{[3
,11
]}

Wu, Ruicheng ^{[1
]}

Tuo, Zhouting ^{[4
]}

Wang, Jie ^{[1
]}

Ye, Luxia ^{[5
]}

Guo, Yiqing ^{[5
]}

Yoo, Koo Han ^{[6
]}

Ke, Mang ^{[5
,12
]}

Okoli, Uzoamaka Adaobi ^{[7
,8
]}

Premkamon, Chaipanichkul ^{[7
]}

Yang, Yubo ^{[9
]}

Wei, Wuran ^{[1
]}

Heavey, Susan ^{[7
]}

Cho, William C. ^{[10
]}

Feng, Dechao ^{[1
,7
]}

机构：

[1] Sichuan Univ, West China Hosp, Inst Urol, Dept Urol, Chengdu 610041, Peoples R China

[2] Southwest Med Univ, Affiliated Hosp, Dept Rehabil, Luzhou 646000, Peoples R China

[3] Ningbo Clin Pathol Diag Ctr, Dept Pathol, Ningbo 315211, Peoples R China

[4] Anhui Med Univ, Affiliated Hosp 2, Dept Urol, Hefei 230601, Peoples R China

[5] Wenzhou Med Univ, Taizhou Hosp Zhejiang Prov, Dept Publ Res Platform, Linhai 317000, Peoples R China

[6] Kyung Hee Univ, Dept Urol, Seoul, South Korea

[7] UCL, Div Surg & Intervent Sci, London W1W 7TS, England

[8] Univ Nigeria, Coll Med, Dept Pharmacol & Therapeut, Basic & Translat Canc Res Grp, Nsukka, Enugu State, Nigeria

[9] Chongqing Univ, Three Gorges Hosp, Dept Urol, Chongqing 404000, Peoples R China

[10] Queen Elizabeth Hosp, Dept Clin Oncol, Hong Kong, Peoples R China

[11] Lihuili Hosp, Ningbo Med Ctr, Dept Pathol, Ningbo, Peoples R China

[12] Wenzhou Med Univ, Taizhou Hosp Zhejiang Prov, Dept Urol, Taizhou, Peoples R China

来源：

CELL COMMUNICATION AND SIGNALING | 2024年 / 22卷 / 01期

关键词：

Tumor microenvironment; Infiltrated cells; Drug resistance; Immunotherapy; Targeted therapy; Radiotherapy; CANCER-CELLS; FIBROBLASTS; INHIBITION; RADIORESISTANCE; CHEMORESISTANCE; CONTRIBUTES; MACROPHAGES; METABOLISM; ACTIVATION; PD-L1;

D O I：

10.1186/s12964-024-01776-7

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Drug resistance remains a significant challenge in cancer treatment. Recently, the interactions among various cell types within the tumor microenvironment (TME) have deepened our understanding of the mechanisms behind treatment resistance. Therefore, this review aims to synthesize current research focusing on infiltrating cells and drug resistance suggesting that targeting the TME could be a viable strategy to combat this issue. Numerous factors, including inflammation, metabolism, senescence, hypoxia, and angiogenesis, contribute to drug resistance could be a viable strategy to combat this issue. Overexpression of STAT3 is commonly associated with drug-resistant cancer cells or stromal cells. Current research often generalizes the impact of stromal cells on resistance, lacking specificity and statistical robustness. Thus, future research should take notice of this issue and aim to provide high-quality evidence. Despite the existing limitations, targeting the TME to overcome therapy resistance hold promising and valuable potential.

引用

页数：17

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