Bioactivity of 2-(3,4-Dihydroxyphenyl)-5,7-dihydroxy-2,3-dihydrochromen-4-one from pistacia chinensis on ENPP1 and aldose reductase

被引：0
|
作者：
Rauf, Abdur [1 ]
Naz, Saima [2 ]
Akram, Zuneera [3 ]
Saleem, Muhammad [4 ]
Alomar, Taghrid S. [5 ]
Almasoud, Najla [5 ]
Ribaudo, Giovanni [6 ]
机构：
[1] Univ Swabi, Dept Chem, Swabi, Pakistan
[2] Bacha Khan Univ Charsadda, Dept Biotechnol, Charsadda, Pakistan
[3] Baqai Med Univ, Fac Pharmaceut Sci, Dept Pharmacol, Karachi, Pakistan
[4] Ghazi Univ, Dept Chem, Dera Ghazi Khan, Pakistan
[5] Princess Nourah bint Abdulrahman Univ, Coll Sci, Dept Chem, Riyadh, Saudi Arabia
[6] Univ Brescia, Dept Mol & Translat Med, Brescia, Italy
来源：
NATURAL PRODUCT RESEARCH | 2024年
关键词：
Pistacia chinensis; flavonoids; ENPP1; aldose reductase; eriodictyol;
D O I：
10.1080/14786419.2024.2344744
中图分类号：
O69 [应用化学];
学科分类号：
081704 ;
摘要：
Pistacia chinensis is used as a decorative tree and currently studied as a source of biofuels. Besides, its parts and extracts are endowed with several therapeutic uses which have been widely explored in traditional medicine and that are related to its rich composition in phytochemicals. Molecular docking and enzymatic inhibition tests were used to study the activity of eriodictyol, a flavonoid extracted from the barks of P. chinensis, against ectonucleotide pyrophosphatase/phosphodiesterase 1 (ENPP1) and aldose reductase (ALR2). The compound was highlighted as a micromolar inhibitor in vitro (IC50 = 263.76 +/- 1.32 mu M and 4.21 +/- 0.94 mu M, respectively) and docking showed that eriodictyol efficiently targets the binding sites of the enzymes. In conclusion, this study unveils the potential of eriodictyol on enzymes that are involved in immunostimulation and in complications of diabetes mellitus. [GRAPHICS]
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页数：5
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