Emerging trends in point-of-care biosensing strategies for molecular architectures and antibodies of SARS-CoV-2

被引：10
作者：
Karuppaiah G. [1 ]
Vashist A. [2 ]
Nair M. [2 ]
Veerapandian M. [1 ,3 ]
Manickam P. [1 ,3 ]
机构：
[1] Electrodics and Electrocatalysis Division, CSIR-Central Electrochemical Research Institute (CECRI), Tamil Nadu, Karaikudi
[2] Center for Personalized Nanomedicine, Institute of NeuroImmune Pharmacology, Department of Immunology, Herbert Wertheim College of Medicine, Florida International University, Miami, 33199, FL
[3] Academy of Scientific and Innovative Research, Uttar Pradesh, Ghaziabad
来源：
Biosensors and Bioelectronics: X | 2023年 / 13卷
关键词：
Biomarkers; COVID-19; Electrochemical and optical biosensors; Infectious diseases; Nanobiosensors;
D O I：
10.1016/j.biosx.2023.100324
中图分类号：
学科分类号：
摘要：
COVID-19, a highly contagious viral infection caused by the occurrence of severe acute respiratory syndrome coronavirus (SARS-CoV-2), has turned out to be a viral pandemic then ravaged many countries worldwide. In the recent years, point-of-care (POC) biosensors combined with state-of-the-art bioreceptors, and transducing systems enabled the development of novel diagnostic tools for rapid and reliable detection of biomarkers associated with SARS-CoV-2. The present review thoroughly summarises and discusses various biosensing strategies developed for probing SARS-CoV-2 molecular architectures (viral genome, S Protein, M protein, E protein, N protein and non-structural proteins) and antibodies as a potential diagnostic tool for COVID-19. This review discusses the various structural components of SARS-CoV-2, their binding regions and the bioreceptors used for recognizing the structural components. The various types of clinical specimens investigated for rapid and POC detection of SARS-CoV-2 is also highlighted. The importance of nanotechnology and artificial intelligence (AI) approaches in improving the biosensor performance for real-time and reagent-free monitoring the biomarkers of SARS-CoV-2 is also summarized. This review also encompasses existing practical challenges and prospects for developing new POC biosensors for clinical monitoring of COVID-19. © The Authors
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