Production of 225Ac for medical application from 232Th-metallic targets in Nb-shells irradiated with middle-energy protons

被引：5

作者：

Ermolaev, Stanislav V. ^{[1
]}

Vasiliev, Aleksandr N. ^{[1
,2
]}

Lapshina, Elena V. ^{[1
]}

Kobtsev, Aleksandr A. ^{[1
]}

Zhuikov, Boris L. ^{[1
]}

机构：

[1] Russian Acad Sci, Inst Nucl Res, Moscow 117312, Russia

[2] Lomonosov Moscow State Univ, Dept Chem, Moscow 119991, Russia

来源：

NEW JOURNAL OF CHEMISTRY | 2024年 / 48卷 / 18期

关键词：

THORIUM TARGETS; CROSS-SECTIONS; ALPHA THERAPY; ACTINIUM-225; AC-225/BI-213; EXTRACTION; (225)AC; BI-213; RA-223; TH-229;

D O I：

10.1039/d3nj05778j

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A method for high-scale Ac-225-production for medical application from a massive metallic Th-232-target irradiated with 160 MeV-protons is described. The target was made of a metallic Th disk of few mm thickness encapsulated in Nb shell using diffusion welding that provided effective target cooling under an intensive proton beam. Chemical processing started with selectively dissolving Nb and Th in mixtures of HF and HNO3 of different concentrations. The further chemical treatment included two sequential extractions of Th(iv) with di(2-ethylhexyl)orthophoshoric acid (HDEHP) and purification of Ac by extraction chromatography with DGA-, LN- and TRU-resins. The "end-to-start" technique, where the eluate of the column filled with one sorbent serves as the eluent for the column with next sorbent, was realized. The achieved total chemical yield of Ac-225 was 87% and radionuclidic purity was better than 99.8% (excepting 0.1-0.2% Ac-227 generated at the end of irradiation). The presented method can provide a hundred GBq of Ac-225 in one irradiation run.

引用

页码：8222 / 8232

页数：11

共 60 条

[1]

Abbas K., 2003, [No title captured], Patent No. [EP1599882, 1599882]

[2]

Abergel R., 2019, J. Med. Imaging Radiat. Sci., DOI [DOI 10.1016/J.JMIR.2019.03.073, 10.1016/j.jmir.2019.03.073]

[3] Bismuth-213 for Targeted Radionuclide Therapy: From Atom to Bedside [J].

Ahenkorah, Stephen ;

Cassells, Irwin ;

Deroose, Christophe M. ;

Cardinaels, Thomas ;

Burgoyne, Andrew R. ;

Bormans, Guy ;

Ooms, Maarten ;

Cleeren, Frederik .

PHARMACEUTICS, 2021, 13 (05)

[4] ISOLATION OF MEDICINE-APPLICABLE ACTINIUM-225 FROM THORIUM TARGETS IRRADIATED BY MEDIUM-ENERGY PROTONS [J].

Aliev, R. A. ;

Ermolaev, S. V. ;

Vasiliev, A. N. ;

Ostapenko, V. S. ;

Lapshina, E. V. ;

Zhuikov, B. L. ;

Zakharov, N. V. ;

Pozdeev, V. V. ;

Kokhanyuk, V. M. ;

Myasoedov, B. F. ;

Kalmykov, S. N. .

SOLVENT EXTRACTION AND ION EXCHANGE, 2014, 32 (05) :468-477

[5] A comparative evaluation of Ac225 vs Bi213 as therapeutic radioisotopes for targeted alpha therapy for cancer [J].

Allen, Barry J. .

AUSTRALASIAN PHYSICAL & ENGINEERING SCIENCES IN MEDICINE, 2017, 40 (02) :369-376

[6]

[Anonymous], 2018, REP JOINT IAEA JRC W

[7]

[Anonymous], 2012, ANSYS MULT AC LIC RE

[8]

[Anonymous], 1962, METALLURGY THORIUM P, V22

[9] Production of Ac-225 from Th-229 for targeted α therapy [J].

Apostolidis, C ;

Molinet, R ;

Rasmussen, G ;

Morgenstern, A .

ANALYTICAL CHEMISTRY, 2005, 77 (19) :6288-6291

[10] Study of the chemical behavior of hydrofluoric, nitric and sulfuric acids mixtures applied to niobium polishing [J].

Aspart, A ;

Antoine, CZ .

APPLIED SURFACE SCIENCE, 2004, 227 (1-4) :17-29

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