Effect of Sciadonic Acid on Hepatic Lipid Metabolism in Obese Mice Induced by A High-fat Diet

被引：0

作者：

Yang X. ^{[1
,2
]}

Yao S. ^{[1
,2
]}

Lu H. ^{[2
]}

Jiang C. ^{[2
]}

Hu W. ^{[2
]}

Feng Y. ^{[3
]}

Chen Z. ^{[3
]}

Shen G. ^{[2
]}

Xiang X. ^{[1
,3
]}

Chen L. ^{[2
]}

机构：

[1] Zhejiang University of Technology, College of Food Science and Technology, Huzhou

[2] Zhejiang Academy of Agricultural Sciences, Institute of Sericultural and Tea, Hangzhou

[3] Zhuji Lükang Biotechnology Co., Ltd., Shaoxing

来源：

Science and Technology of Food Industry | 2024年 / 45卷 / 06期

关键词：

high-fat diet; lipid metabolism; mice; obesity; sciadonic acid;

D O I：

10.13386/j.issn1002-0306.2023040023

中图分类号：

学科分类号：

摘要：

Objective: To investigate the potential beneficial effects of sciadonic acid (SA) on improving obesity induced by a high-fat diet in mice. Methods: Forty-eight male C57BL/6 mice were adaptively fed for one week and then randomly divided into the following groups: Control group (C), positive control group (S), model group (M), low-dose sciadonic acid group (LSA), medium-dose sciadonic acid group (MSA), and high-dose sciadonic acid group (HSA). The modeling process lasted for 16 weeks, and the low and high-dose groups were orally administered different doses of SA solution at a fixed time each day. After the modeling period, potential mechanisms of SA in regulating lipid metabolism in obese mice were explored, including aspects such as blood lipid metabolism, hepatic fat metabolism, hepatic oxidative stress, hepatic lipid synthesis, and expression of metabolism-related genes. Results: The high-dose SA intervention in obese mice significantly decreased the levels of total cholesterol (TC), triglycerides (TG), and low-density lipoprotein cholesterol (LDL-C) in serum, while increasing high-density lipoprotein cholesterol (HDL-C) (P<0.05). It inhibited weight gain, reduced epididymal fat accumulation, and improved liver tissue damage. Additionally, SA significantly increased the activities of antioxidant enzymes such as superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) in mice (P<0.05), and significantly reduced the production of oxidative end products MDA (P<0.05), alleviated oxidative stress in vivo, and inhibited lipid synthesis by regulating the expression of genes related to lipid metabolism to improve lipid metabolism. Conclusion: SA could improve lipid metabolism disorders in obese mice by suppressing fat accumulation, alleviate oxidative stress, regulate lipid synthesis and metabolism. © 2024 Editorial Department of Science and Technology of Food Science. All rights reserved.

引用

页码：304 / 312

页数：8

共 42 条

[1]

WANG H, LI Y, WANG R, Et al., Chinese Torreya grandis cv. Merrillii seed oil affects obesity through accumulation of sciadonic acid and altering the composition of gut microbiota[J], Food Science and Human Wellness, 11, 1, pp. 58-67, (2022)

[2]

KIM S, HENNEICKE H, CAVANAGH L ., Et al., Osteoblastic glucocorticoid signaling exacerbates high-fat-diet induced bone loss and obesity[J], Bone Research, 9, 4, pp. 537-548, (2021)

[3]

PAN X F, WANG L M, PAN A., Epidemiology and determinants of obesity in China[J], The Lancet Diabetes & Endocrinology, 9, 6, pp. 373-392, (2021)

[4]

BU J, CHEN Z W, CUI X T, Et al., Current status ot metabolic abnormality & treatment of cardiovascular diseases in Chinese adults, Shanghai Medical & Pharmaceutical Journal, 43, 3, pp. 129-164, (2020)

[5]

JOHN G K, WANG L, NANAVATI J, Et al., Dietary alteration of the gut microbiome and its impact on weight and fat mass:A systematic review and meta-analysis[J], Genes, 9, 3, (2018)

[6]

LI S, ZHAO J H, LUAN J, Et al., Genetic predisposition to obesity leads to increased risk of type 2 diabetes[J], Diabetologia, 54, 4, pp. 776-782, (2011)

[7]

FUJII R, PATTARO C., Genetically-instrumented public health:Facing obesity to prevent chronic kidney disease, Cardiovascular research, 18, 5, pp. 3013-3015, (2022)

[8]

ANCA T, ADRIAN R, REMUS S, Et al., Clinical and laboratory characteristics of normal weight and obese individuals with nonalcoholic fatty liver disease[J], Diagnostics, 12, 4, (2022)

[9]

CONNOLLY K, BATACAN R J, JACKSON D, Et al., Perindopril prevents development of obesity and hypertension in middle aged diet-induced obese rat models of metabolic syndrome [J], Life Sciences, 314, (2022)

[10]

TIM B, REBECCA L S., Body fatness as a cause of cancer:Epidemiologic clues to biologic mechanisms, Endocrine-related cancer, 22, 3, pp. R125-R134, (2015)

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