Novel automated AIMLAM for diagnosis of Mycobacterium tuberculosis

被引：0

作者：

Liang, Ruixia ^{[1
]}

Li, Jiankang ^{[1
]}

Shi, Hongmei ^{[1
]}

Wu, Han ^{[1
]}

Zhao, Chang ^{[1
]}

机构：

[1] Henan Prov Chest Hosp, Henan Infect Dis TB Clin Res Ctr, 1 Weiwu Rd, Zhengzhou, Henan, Peoples R China

来源：

FUTURE MICROBIOLOGY | 2024年 / 19卷 / 09期

关键词：

AIMLAM; lipoarabinomannan; Mycobacterium tuberculosis; TB; RESISTANT TUBERCULOSIS; LIPOARABINOMANNAN; HOUSEHOLD; ASSAYS; HIV; TB;

D O I：

10.2217/fmb-2024-0025

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Aim: A rapid and precise diagnostic method is crucial for timely intervention and management of tuberculosis. The present study compared the diagnostic accuracy of a novel lipoarabinomannan (LAM) antigen test, AIMLAM, for tuberculosis in urine samples. Methodology: The study subjected 106 TB suspects to smear microscopy, MGIT, GeneXpert and AIMLAM. Results: Among 106, smear microscopy identified 36 as positive (33%) (sensitivity; 70.93%, 95% CI (60.14-80.22%), while MGIT showed 38 positive (36.8%). GeneXpert detected 59 positives (sensitivity; 96.83, 95% CI (89.00-99.61%)). AIMLAM declared 61 as positive (57.5%) (sensitivity; 100.00, 95% CI (94.13-100.00%) and 45 as negative (42.5%). Conclusion: Overall, AIMLAM demonstrated better diagnostic accuracy than GeneXpert Assay, smear microscopy and MGIT liquid culture in urine samples.

引用

页码：783 / 793

页数：11

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