Microglial Dysfunction in Autism Spectrum Disorder

被引：2

作者：

Meng, Jian ^{[1
,2
]}

Zhang, Lingliang ^{[1
,2
]}

Zhang, Yun-wu ^{[1
,2
]}

机构：

[1] Xiamen Univ, Inst Neurosci, Sch Med, Fujian Prov Key Lab Neurodegenerat Dis & Aging Res, Xiamen 361102, Fujian, Peoples R China

[2] Xiamen Univ, Affiliated Hosp 1, Xiamen Key Lab Brain Ctr, Sch Med, Xiamen, Peoples R China

来源：

NEUROSCIENTIST | 2024年 / 30卷 / 06期

基金：

中国国家自然科学基金; 中国博士后科学基金;

关键词：

autism spectrum disorder; autophagy; gut microbiota; microglia; neuroinflammation; synaptic pruning; transcriptome; BEHAVIORAL ABNORMALITIES; ACTIVATED MICROGLIA; COMPLEMENT-SYSTEM; BRAIN; INHIBITION; AUTOPHAGY; PHAGOCYTOSIS; INFLAMMATION; CHILDREN; TURNOVER;

D O I：

10.1177/10738584241252576

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Autism spectrum disorder (ASD) is a highly heterogeneous neurodevelopmental disorder with onset in childhood. The molecular mechanisms underlying ASD have not yet been elucidated completely. Evidence has emerged to support a link between microglial dysfunction and the etiology of ASD. This review summarizes current research on microglial dysfunction in neuroinflammation and synaptic pruning, which are associated with altered transcriptomes and autophagy in ASD. Dysbiosis of gut microbiota in ASD and its correlation with microglial dysfunction are also addressed.

引用

页码：744 / 758

页数：15

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