Lactobacillus plantarum LPYC225 mixture partially modulates the vaginal bacterial community of Gardnerella vaginalis-infected bacterial vaginosis in mice

被引:2
作者
Kim, Hyun Ju [1 ]
Kim, Dong-Gu [2 ]
Kang, Sa-Haeng [3 ]
Choi, Hoonsung [3 ]
Go, Se-Woong [4 ]
Kim, Dong-Keun [4 ]
Myung, Je-Hun [4 ]
Park, Jeong-Hyang [3 ]
Soh, Ju-Ryoun [3 ]
Kim, Suk-Kyu [3 ]
Hong, Sung Wook [1 ]
Kang, Miran [1 ]
Park, Eui-Seong [5 ]
Park, Ilbum [5 ]
Kang, Jongsoo [5 ]
Kwon, Hyuk Ju [5 ]
Jin, Jong-Sik [3 ]
机构
[1] World Inst Kimchi, Miran Kang Kimchi Ind Promot Div, Gwangju 61755, South Korea
[2] Dong Eui Univ, Dept Korean Med, Busan 47340, South Korea
[3] Jeonbuk Natl Univ, Dept Oriental Med Resources, 79 Gobong Ro, Iksan 54596, South Korea
[4] Jeonbuk Natl Univ, Dept Pharm, Jeonju 54896, South Korea
[5] Yuhan Care Co Ltd, Seoul 07335, South Korea
关键词
Bacterial vaginosis; Lactobacillus; Inflammation; Vaginal bacterial community; HEALTH;
D O I
10.1007/s10068-024-01641-w
中图分类号
TS2 [食品工业];
学科分类号
0832 ;
摘要
Bacterial vaginosis (BV) is defined as dysbiosis of the vaginal microbiome associated with the depletion of Lactobacilli and excessive growth of commensal or pathogenic bacteria. This study investigated the effects of lactic acid bacteria (LAB) mixture (LM; InoRexyne (TM)) on the vaginal bacterial community of Gardnerella vaginalis (G. vaginalis)-infected BV mice. Single LAB and LM exhibited antibacterial and anti-inflammatory effects by inhibiting G. vaginalis growth and pro-inflammatory markers in RAW 264.7 cells. Administering LM did not significantly alter the vaginal architecture or fecal short-chain fatty acids but did significantly inhibit the vaginal interleukin-6 levels in the high LM group compared to the GV group. LM administration decreased the relative abundances of Enterobacter, Escherichia coli, and Bacteroides vulgatus in vaginal flushing fluids compared to the GV group. LM partially alleviated BV by inhibiting G. vaginalis growth and modulating the vaginal bacterial community, providing new insights into its modulatory effects on the vaginal microbiome in BV.
引用
收藏
页码:2233 / 2242
页数:10
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