Correlation Between Dosimetric Parameters and Local Control in Definitive Radiotherapy for Head and Neck Cancers

被引:1
作者
Yamashita, Mikiko [1 ,2 ]
Ohira, Shingo [2 ,3 ]
Tanabe, Hiroaki [1 ]
Kokubo, Masaki [4 ]
Koizumi, Masahiko [2 ]
机构
[1] Kobe City Med Ctr Gen Hosp, Dept Radiol Technol, 2-1-1 Minatojima Minamimachi,Chuo Ku, Kobe, Hyogo 6500047, Japan
[2] Osaka Univ, Grad Sch Med, Dept Med Phys & Engn, Osaka, Japan
[3] Univ Tokyo, Dept Comprehens Radiat Oncol, Tokyo, Japan
[4] Kobe City Med Ctr Gen Hosp, Dept Radiat Oncol, Kobe, Hyogo, Japan
来源
IN VIVO | 2024年 / 38卷 / 02期
关键词
Head and neck cancers; local control; dosimetric parameters; VMAT; Acuros External Beam; ACUROS XB ALGORITHM; MODULATED RADIATION-THERAPY; FDG PET; IMRT; VALIDATION; SURVIVAL; PATTERNS; FAILURE; BEAM; CT;
D O I
10.21873/invivo.13506
中图分类号
R-3 [医学研究方法]; R3 [基础医学];
学科分类号
1001 ;
摘要
Background/Aim: Radiotherapy (RT) outcomes are generally reported based on stage, patient background, and concomitant chemotherapy. This study aimed to investigate the effects of the prescribed dose to gross tumor volume (GTV) and the calculation algorithm on local control in definitive RT for head and neck (H&N) cancers using follow-up images after RT. Patients and Methods: This study included 154 patients with H&N cancers treated by Volumetric Modulated Arc Therapy at the Kobe City Medical Center General Hospital. Patients were classified into those receiving definitive RT (70 Gy of irradiation) and those not receiving it. Follow-up images were used to categorize the patients into the responders and non -responders groups. In the non -responders group, follow-up images were imported into the treatment planning system, and the contours of the residual or recurrent areas (local failure) were extracted and fused with computed tomography -simulated images for treatment planning. Dose evaluation parameters included maximum dose, dose administered to 1% of the volume, dose administered to 50% of the volume, dose administered to 99% of the volume (D99%), and minimum dose (Dmin) administered to the GTV. The doses to the GTV were compared between responders and non -responders. Results: D99% exhibited significant differences between local failure and responders and between local failure and nonresponders. Dmin showed significant differences between responders and non -responders and between responders and local failure. Conclusion: This study emphasizes the importance of verifying dose distribution in all slices of treatment planning, highlighting the need for precise assessment of the dose to the GTV in head and neck cancers.
引用
收藏
页码:819 / 825
页数:7
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