Late dental and bone alterations in patients after orbital rhabdomyosarcoma treatment

被引:0
作者
de Mattos, Valkiria D. Aiuto [1 ]
Ferman, Sima Esther [1 ]
Magalhaes, Denise Maria Araujo [2 ]
da Costa, Felipe Vieira [3 ]
Antunes, Heliton Spindola [4 ]
Silva Junior, Arley [5 ]
机构
[1] Inst Nacl Canc Inca, Pathol Div, Rio De Janeiro, RJ, Brazil
[2] Inst Nacl Canc Inca, Pathol Div, Rio De Janeiro, RJ, Brazil
[3] Univ Fed Fluminense UFF, Dept Sociol, Niteroi, RJ, Brazil
[4] Inst Nacl Canc INCA, Clin Res Div, Rua Andre Cavalcante 37,2 Andar, BR-20231050 Rio De Janeiro, RJ, Brazil
[5] Univ Fed Fluminense UFF, Pathol Dept, Niteroi, RJ, Brazil
关键词
Orbit; Orbit tumor; Children; Rhabdomyosarcoma; Embryonic orbital rhabdomyosarcoma; INTERGROUP RHABDOMYOSARCOMA; SOFT-TISSUE; EMBRYONAL RHABDOMYOSARCOMA; NECK RHABDOMYOSARCOMA; CHILDREN; HEAD; SARCOMA; EXPERIENCE; ADOLESCENTS; SURVIVAL;
D O I
10.1007/s00520-024-08843-2
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
PurposeOrbital rhabdomyosarcoma is a rare soft tissue sarcoma in childhood but with a good prognosis. Treatment usually includes surgery, chemotherapy, and radiotherapy. This study aimed to evaluate long-term alterations in teeth and cranial bones in children, adolescents, and young adults after oncologic treatment for childhood orbital rhabdomyosarcoma.MethodThis was a cross-sectional study that evaluated patients treated for orbital rhabdomyosarcoma between 1988 and 2011. Demographic, clinical, and treatment data were collected during the study period; also, panoramic radiographs, cephalometric study, and photographs of the face were taken.ResultsEight long-term survivors were studied. Of those, 50% were male, 75% had less than 5 years of treatment, and 88% had only one of the orbits affected by the tumor. Regarding treatment, 50% received 50.4 Gy of radiotherapy in the orbit; the chemotherapy included vincristine, actinomycin D, and cyclophosphamide in 75% of the cases and also ifosfamide and etoposide in 25%. The children presented craniofacial alterations, mainly when radiotherapy occurred between 0 and 5 years old (p = 0.01). The mandibles also showed dental alterations, probably due to chemotherapy.ConclusionIn conclusion, orbital RMS patients treated with chemoradiotherapy, important dental, and facial bone alterations were found. The most significant were in the maxilla and close to the irradiation field. Dental and mandibular bone alterations were also found, indicating the probable chemotherapy action, as this region was not included in the irradiation field.
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页数:9
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