Pharmacotherapy for Coronary Artery Disease and Acute Coronary Syndrome in the Aging Population

被引：2

作者：

Moras, Errol ^{[1
]}

Zaid, Syed ^{[2
]}

Gandhi, Kruti ^{[1
]}

Barman, Nitin ^{[3
]}

Birnbaum, Yochai ^{[2
]}

Virani, Salim S. ^{[4
]}

Tamis-Holland, Jacqueline ^{[5
]}

Jneid, Hani ^{[6
]}

Krittanawong, Chayakrit ^{[7
,8
]}

机构：

[1] Icahn Sch Med Mt Sinai, Dept Internal Med, New York, NY USA

[2] Baylor Coll Med, Sect Cardiol, Houston, TX 77030 USA

[3] Mt Sinai Morningside Hosp, Cardiac Catheterizat Lab, New York, NY USA

[4] Aga Khan Univ, Karachi, Pakistan

[5] Cleveland Clin, Heart Vasc & Thorac Inst, Cleveland, OH USA

[6] Univ Texas Med Branch, Div Cardiol, Houston, TX USA

[7] NYU Langone Hlth, Cardiol Div, New York, NY 10016 USA

[8] NYU Sch Med, New York, NY 10016 USA

来源：

CURRENT ATHEROSCLEROSIS REPORTS | 2024年 / 26卷 / 07期

关键词：

Coronary artery disease; Acute coronary syndromes; Pharmacotherapy; Older adults; Revascularization; ACUTE MYOCARDIAL-INFARCTION; BETA-BLOCKER THERAPY; LEFT-VENTRICULAR DYSFUNCTION; REDUCED EJECTION FRACTION; NURSING-HOME RESIDENTS; DRUG-DRUG INTERACTIONS; BYPASS GRAFT-SURGERY; SCIENTIFIC STATEMENT; ATRIAL-FIBRILLATION; ELDERLY-PATIENTS;

D O I：

10.1007/s11883-024-01203-9

中图分类号：

R6 [外科学];

学科分类号：

1002 ; 100210 ;

摘要：

Purpose of ReviewTo provide a comprehensive summary of relevant studies and evidence concerning the utilization of different pharmacotherapeutic and revascularization strategies in managing coronary artery disease and acute coronary syndrome specifically in the older adult population.Recent findingsApproximately 30% to 40% of hospitalized patients with acute coronary syndrome are older adults, among whom the majority of cardiovascular-related deaths occur. When compared to younger patients, these individuals generally experience inferior clinical outcomes. Most clinical trials assessing the efficacy and safety of various therapeutics have primarily enrolled patients under the age of 75, in addition to excluding those with geriatric complexities.SummaryIn this review, we emphasize the need for a personalized and comprehensive approach to pharmacotherapy for coronary heart disease and acute coronary syndrome in older adults, considering concomitant geriatric syndromes and age-related factors to optimize treatment outcomes while minimizing potential risks and complications. In the realm of clinical practice, cardiovascular and geriatric risks are closely intertwined, with both being significant factors in determining treatments aimed at reducing negative outcomes and attaining health conditions most valued by older adults.

引用

页码：231 / 248

页数：18

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