Radiation-induced cutaneous squamous cell carcinoma showing a significant response to pembrolizumab: A case report

被引：1
|
作者：
Takahashi-Watanabe, Manami [1 ]
Fujimura, Taku [1 ,3 ]
Amagai, Ryo [1 ]
Ohuchi, Kentaro [1 ]
Yamazaki, Emi [1 ]
Tamabuchi, Erika [1 ]
Kuroki, Shigeru [2 ]
Kambayashi, Yumi [1 ]
Hashimoto, Akira [1 ]
Asano, Yoshihide [1 ]
机构：
[1] Tohoku Univ, Grad Sch Med, Dept Dermatol, Sendai, Japan
[2] Sendai Tokushukai Hosp, Dept Dermatol, Sendai, Japan
[3] Tohoku Univ, Grad Sch Med, Dept Dermatol, 1-1 Seiryo machi,Aoba ku, Sendai, Miyagi 9808574, Japan
来源：
JOURNAL OF DERMATOLOGY | 2024年 / 51卷 / 11期
关键词：
mycosis fungoides; pembrolizumab; radiation-induced cSCC; OPEN-LABEL; T-CELLS;
D O I：
10.1111/1346-8138.17221
中图分类号：
R75 [皮肤病学与性病学];
学科分类号：
100206 ;
摘要：
Cutaneous squamous cell carcinoma (cSCC) arising from radiation dermatitis has a higher risk of metastasis than conventional cSCC. Immunosuppression is another risk factor for cSCC, suggesting that mycosis fungoides (MF) could be a risk factor for cSCC. Here we report a case of radiation-induced cSCC with a high level of tumor-mutation burden that developed in a patient with MF who was successfully treated with pembrolizumab. The present case suggests that pembrolizumab might be an optimal therapy for radiation-induced cSCC, even at advanced stages.
引用
收藏
页码：1500 / 1503
页数：4
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