A biodegradable and flexible neural interface for transdermal optoelectronic modulation and regeneration of peripheral nerves

被引：11

作者：

Sun, Pengcheng ^{[1
]}

Li, Chaochao ^{[2
]}

Yang, Can ^{[1
]}

Sun, Mengchun ^{[2
]}

Hou, Hanqing ^{[3
]}

Guan, Yanjun ^{[2
]}

Chen, Jinger ^{[1
]}

Liu, Shangbin ^{[1
]}

Chen, Kuntao ^{[1
]}

Ma, Yuan ^{[4
]}

Huang, Yunxiang ^{[5
]}

Li, Xiangling ^{[2
,6
]}

Wang, Huachun ^{[7
]}

Wang, Liu ^{[8
,9
]}

Chen, Shengfeng ^{[2
]}

Cheng, Haofeng ^{[2
]}

Xiong, Wei ^{[10
]}

Sheng, Xing ^{[11
,12
,13
]}

Zhang, Milin ^{[4
]}

Peng, Jiang ^{[2
,14
]}

Wang, Shirong ^{[15
]}

Wang, Yu ^{[2
,14
]}

Yin, Lan ^{[1
]}

机构：

[1] Tsinghua Univ, Sch Mat Sci & Engn, State Key Lab New Ceram & Fine Proc, Key Lab Adv Mat,Minist Educ,Lab Flexible Elect Tec, Beijing 100084, Peoples R China

[2] Chinese Peoples Liberat Army Gen Hosp, Inst Orthoped, Key Lab Musculoskeletal Trauma & Injuries PLA, Beijing Key Lab Regenerat Med Orthoped, 28 Fuxing Rd, Beijing 100853, Peoples R China

[3] Tsinghua Univ, Sch Life Sci, Beijing 100084, Peoples R China

[4] Tsinghua Univ, Dept Elect Engn, Beijing 100084, Peoples R China

[5] Dartmouth Coll, Thayer Sch Engn, Hanover, NH 03755 USA

[6] Huazhong Univ Sci & Technol, Tongji Hosp, Tongji Med Coll, Dept Rehabil, Wuhan 430030, Peoples R China

[7] Sun Yat Sen Univ, Sch Integrated Circuits, Shenzhen Campus, Shenzhen 518107, Peoples R China

[8] Beihang Univ, Beijing Adv Innovat Ctr Biomed Engn, Sch Biol Sci & Med Engn, Key Lab Biomech & Mechanobiol,Minist Educ, Beijing 100083, Peoples R China

[9] Beihang Univ, Sch Engn Med, Beijing 100083, Peoples R China

[10] Chinese Inst Brain Res, Beijing 102206, Peoples R China

[11] Tsinghua Univ, Beijing Natl Res Ctr Informat Sci & Technol, Dept Elect Engn, Lab Flexible Elect Technol, Beijing 100084, Peoples R China

[12] Tsinghua Univ, Inst Precis Med, Beijing 100084, Peoples R China

[13] Tsinghua Univ, McGovern Inst Brain Res, IDG, Beijing 100084, Peoples R China

[14] Nantong Univ, Coinnovat Ctr Neuroregenerat, Nantong 226007, Peoples R China

[15] MegaRobo Technol Co ltd, Beijing 100085, Peoples R China

来源：

NATURE COMMUNICATIONS | 2024年 / 15卷 / 01期

基金：

中国国家自然科学基金; 北京市自然科学基金;

关键词：

VAGUS NERVE; STIMULATION; NEUROMODULATION; OPTOGENETICS; SENSITIVITY; DEVICES;

D O I：

10.1038/s41467-024-49166-4

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Optoelectronic neural interfaces can leverage the photovoltaic effect to convert light into electrical current, inducing charge redistribution and enabling nerve stimulation. This method offers a non-genetic and remote approach for neuromodulation. Developing biodegradable and efficient optoelectronic neural interfaces is important for achieving transdermal stimulation while minimizing infection risks associated with device retrieval, thereby maximizing therapeutic outcomes. We propose a biodegradable, flexible, and miniaturized silicon-based neural interface capable of transdermal optoelectronic stimulation for neural modulation and nerve regeneration. Enhancing the device interface with thin-film molybdenum significantly improves the efficacy of neural stimulation. Our study demonstrates successful activation of the sciatic nerve in rodents and the facial nerve in rabbits. Moreover, transdermal optoelectronic stimulation accelerates the functional recovery of injured facial nerves. Optoelectronic neural interfaces allow for non-genetic and remote modulation of neural activity. Here, the authors propose a biodegradable, flexible and miniaturized neural interface based on molybdenum-modified silicon diodes that allows transdermal neuromodulation and promotes nerve regeneration.

引用

页数：14

共 89 条

[1]

Al-Majed AA, 2000, J NEUROSCI, V20, P2602

[2] Drug Repurposing in Parkinson's Disease [J].