Extention and interlaboratory comparison of an LC-MS/MS multi-class method for the determination of 15 different classes of veterinary drug residues in milk and poultry feed

被引:3
作者
Kenjeric, Lidija [1 ,2 ]
Sulyok, Michael [2 ]
Malachova, Alexandra [1 ]
Greer, Brett [3 ]
Kolawole, Oluwatobi [3 ]
Quinn, Brian [3 ]
Elliott, Christopher T. [3 ,4 ]
Krska, Rudolf [2 ,3 ]
机构
[1] FFoQSI GmbH, FFoQSI Austrian Competence Ctr Feed & Food Qual Sa, Tulln, Austria
[2] Univ Nat Resource & Life Sci, Inst Bioanalyt & Agrometabol, Dept Agrobiotechnol, IFA Tulln, Konrad Lorenz Str 20, A-3430 Vienna, Austria
[3] Queens Univ Belfast, Inst Global Food Secur, Sch Biol Sci, Univ Rd, Belfast BT7 1NN, North Ireland
[4] Thammasat Univ, Fac Sci & Technol, Sch Food Sci & Technol, 99 Mhu 18,Pahonyothin Rd, Khong Luang 12120, Pathum Thani, Thailand
关键词
LC-MS/MS; Validation; Extraction techniques; Chicken feed; Milk; Interlaboratory comparison; FOOD; PESTICIDES; STRATEGIES; VALIDATION; EXTRACTION;
D O I
10.1016/j.foodchem.2024.138834
中图分类号
O69 [应用化学];
学科分类号
081704 ;
摘要
An HPLC-MS/MS multi-class method for quantitation of 15 different classes of veterinary drug residues (>140 analytes) in milk and poultry feed was developed and validated. Accuracy criteria for routine laboratories were met for the majority of analytes, > 83 % in milk and between 50 and 60 % in chicken feed, with an apparent recovery of 60-140 %. Extraction efficiency criteria were met for >95 % of the analytes for milk and > 80 % for chicken feed. Intermediate precision meets the SANTE criterion of RSD < 20 % for 80-90 % of the analytes in both matrices. For all analytes with an existing MRL in milk, the LOQ was below the related MRL. Twenty-nine samples of commercial milk and chicken feed were analyzed within the interlaboratory comparison. No residues of veterinary drugs were found in the milk samples. However, the feed samples exhibited high levels of nicarbazin, salinomycin, and decoquinate.
引用
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页数:10
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共 32 条
  • [1] [Anonymous], 2011, GUIDELINE BIOANALYTI
  • [2] [Anonymous], 2016, Guidance document on the estimation of LOD and LOQ for measurements in the field of contaminants in feed and food, DOI [10.2787/8931, DOI 10.2787/8931]
  • [3] [Anonymous], 2003, OFFICIAL J EUROPEAN
  • [4] [Anonymous], 2018, Bioanalytical Method Validation Guidance for Industry Biopharmaceutics Bioanalytical Method Validation Guidance for Industry Biopharmaceutics Contains Nonbinding Recommendations
  • [5] Comission, Commission Regulation No. 37/2010 of 22 December 2009 on pharmacologically active substance
  • [6] Screening of veterinary drug residues in food by LC-MS/MS. Background and challenges
    Delatour, Thierry
    Racault, Lucie
    Bessaire, Thomas
    Desmarchelier, Aurelien
    [J]. FOOD ADDITIVES AND CONTAMINANTS PART A-CHEMISTRY ANALYSIS CONTROL EXPOSURE & RISK ASSESSMENT, 2018, 35 (04): : 632 - 645
  • [7] Stability study of veterinary drugs in standard solutions for LC-MS/MS screening in food
    Desmarchelier, Aurelien
    Feuerrigel, Philipp
    Ahmed, Hassan Fathi
    Moulin, Julie
    Beck, Andrea
    Mujahid, Claudia
    Bessaire, Thomas
    Savoy, Marie-Claude
    Mottier, Pascal
    [J]. FOOD ADDITIVES AND CONTAMINANTS PART A-CHEMISTRY ANALYSIS CONTROL EXPOSURE & RISK ASSESSMENT, 2018, 35 (04): : 695 - 705
  • [8] Theory and methodology of antibiotic extraction from biomatrices
    Fedeniuk, RW
    Shand, PJ
    [J]. JOURNAL OF CHROMATOGRAPHY A, 1998, 812 (1-2) : 3 - 15
  • [9] Development and validation of a LC-MS/MS method for the simultaneous determination of aflatoxins, dyes and pesticides in spices
    Ferrer Amate, C.
    Unterluggauer, H.
    Fischer, R. J.
    Fernandez-Alba, A. R.
    Masselter, S.
    [J]. ANALYTICAL AND BIOANALYTICAL CHEMISTRY, 2010, 397 (01) : 93 - 107
  • [10] Food and Agriculture Organization (FAO), THE STATE OF FOOD AND AGRICULTURE WOMEN IN AGRICULTURE Closing the gender gap for development (2010-11)