IMPROVE-BMT: A Pilot Randomized Controlled Trial of Prehabilitation Exercise for Adult Hematopoietic Stem Cell Transplant Recipients

被引:1
作者
Potiaumpai, Melanie [1 ]
Caru, Maxime [2 ]
Mineishi, Shin [3 ]
Naik, Seema [3 ]
Zemel, Babette S. [4 ,5 ]
Schmitz, Kathryn H. [1 ]
机构
[1] Univ Pittsburgh, Sch Med, Dept Med, 5051 Ctr Ave, Pittsburgh, PA 15213 USA
[2] Penn State Univ, Coll Med, Dept Pediat, 500 Univ Dr,POB 850, Hershey, PA 17033 USA
[3] Penn State Univ, Penn State Canc Inst, Coll Med, 500 Univ Dr,POB 850, Hershey, PA 17033 USA
[4] Childrens Hosp Philadelphia, Div Gastroenterol Hepatol & Nutr, 3401 Civ Ctr Blvd, Philadelphia, PA 19104 USA
[5] Univ Penn, Perelmen Sch Med, Dept Pediat, 3400 Civ Ctr Blvd, Philadelphia, PA 19104 USA
基金
美国国家卫生研究院;
关键词
allogeneic stem cell transplant; autologous stem cell transplant; cancer; exercise; exercise oncology; oncology; pre-transplant exercise; physical function; prehabilitation; 6-MINUTE WALK TEST; BONE-MARROW-TRANSPLANTATION; PHYSICAL PERFORMANCE; IMPORTANT DIFFERENCE; BALANCE SCALE; MUSCLE MASS; STRENGTH; RELIABILITY; HEALTH; VALIDATION;
D O I
10.3390/jcm13072052
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Background: There is limited evidence on the effects of aerobic and resistance training exercise interventions to improve physical function and patient-reported outcomes prior to autologous and allogeneic hematopoietic stem cell transplant (HSCT). IMPROVE-BMT was a single-site, pilot randomized controlled trial investigating the feasibility, acceptability, and safety of a pragmatic resistance training exercise program prior to HSCT compared to usual HSCT care. Secondary aims included differences in physical function between the exercise group (EX) and usual care control group (UC). Methods: Outcome measurements were assessed: prior to HSCT, on/around day of HSCT admission, +30 days post-HSCT, and +100 days post-HSCT. The exercise intervention was a home-based exercise program that incorporated resistance-band and bodyweight exercises. Results: Acceptability among participants was 83%; exercise adherence averaged at 92%; and there were zero exercise-related adverse or serious adverse events. The average pre-transplant exercise phase was 6.28 weeks (2.71-18.29 weeks). EX (n = 36) demonstrated larger increases in the six-minute walk test distance, short physical performance battery scores, and 30-s chair stands compared to UC (n = 38) and demonstrated significant within-group improvements for the six-minute walk test, the short physical performance battery, the 30-s chair stands, and the timed up-and-go test. Conclusions: IMPROVE-BMT demonstrates that pragmatic exercise is highly feasible for HSCT recipients and can potentially lead to enhanced recovery that may not be achievable in non-exercisers.
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页数:15
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