Incidence and prevalence of musculoskeletal health conditions in survivors of childhood and adolescent cancers: A report from the Swiss childhood cancer survivor study

被引:5
作者
Christen, Salome [1 ]
Roser, Katharina [1 ]
Mader, Luzius [2 ]
Otth, Maria [1 ,3 ,4 ]
Scheinemann, Katrin [1 ,4 ,5 ,6 ]
Sommer, Grit [7 ]
Kuehni, Claudia [7 ,8 ]
Michel, Gisela [1 ]
机构
[1] Univ Lucerne, Fac Hlth Sci & Med, Luzern, Switzerland
[2] Univ Bern, Canc Registry Bern Solothurn, Bern, Switzerland
[3] Univ Childrens Hosp Zurich, Dept Oncol, Zurich, Switzerland
[4] Childrens Hosp Eastern Switzerland, Div Pediat Hematol Oncol, St Gallen, Switzerland
[5] McMaster Childrens Hosp, Dept Pediat, Hamilton, ON, Canada
[6] McMaster Univ, Hamilton, ON, Canada
[7] Univ Bern, Inst Social & Prevent Med, Swiss Childhood Canc Registry, Bern, Switzerland
[8] Univ Bern, Bern Univ Hosp, Inselspital, Dept Pediat,Div Pediat Hematol Oncol, Bern, Switzerland
关键词
childhood cancer; musculoskeletal health conditions; registry; scoliosis; survivors; Switzerland; QUALITY-OF-LIFE; CUMULATIVE BURDEN; PHYSICAL-THERAPY; COHORT; IMPACT;
D O I
10.1002/cam4.7204
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Purpose: Childhood cancer and its treatment can cause damage to the musculoskeletal system. We aimed to determine the incidence and prevalence of musculoskeletal health conditions (MSHC) in survivors, and to investigate differences by cancer-related characteristics. Methods: We used data from the Childhood Cancer Registry and the Swiss Childhood Cancer Survivor Study, including survivors (>= 5 years since diagnosis; diagnosed 1976-2015 at <20 years of age) aged >= 15 years at study. Cumulative incidence and prevalence of MSHCs (osteoporosis, limb length discrepancy, limited joint mobility, bone/joint pain, scoliosis, changes to chest/ribs and amputation) were calculated from self-reported data. Results: We included 2645 survivors (53% men; median age 24 years, range 15-59 years). Prevalence and cumulative incidence of any MSHC was 21% and 26%, respectively. Incidence rate for any MSHC was 15.6/1000 person-years. Scoliosis (8%), bone/joint pain (7%) and limited joint mobility (7%) were the most prevalent MSHC. MSHC co-occurred with other health conditions in 87% of survivors. We found increased rates of MSHC in women (RR = 1.4, 95%CI: 1.2-1.7), bone tumour survivors (RR = 6.0, 95%CI: 4.5-7.9), survivors older at diagnosis (11-15 years: RR = 1.8, 95%CI: 1.5-2.3), after a relapse (RR = 1.5, 95%CI: 1.3-1.9), treatment with surgery (RR = 1.2, 95%CI: 1.0-1.5), chemotherapy (RR = 1.4, 95%CI: 1.1-1.8) or stem cell transplantation (RR = 1.6, 95%CI: 1.0-2.5), and more recent year of diagnosis (2011-2015: RR = 4.3, 95%CI: 2.8-6.8). Conclusion: MSHCs are prevalent in survivors, the risk is increasing in younger survivor cohorts, and MSHCs usually occur in multimorbid survivors. Strengthening of rehabilitation services and appropriate referrals are needed to mitigate the effects of the cancer and cancer treatment.
引用
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页数:13
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