Complexities in Adjuvant Endocrine Therapy for Breast Cancer in Female-to-Male Transgender Patients

被引：0

作者：

Sato, Shoko ^{[1
]}

Imada, Sae ^{[1
]}

Hayami, Ryosuke ^{[1
]}

Arai, Kazumori ^{[2
]}

Kosugi, Rieko ^{[3
]}

Tsuneizumi, Michiko ^{[1
]}

Matsunuma, Ryoichi ^{[1
]}

机构：

[1] Shizuoka Prefectural Gen Hosp, Dept Breast Surg, Shizuoka, Japan

[2] Shizuoka Prefectural Gen Hosp, Dept Pathol, Shizuoka, Japan

[3] Shizuoka Prefectural Gen Hosp, Ctr Diabet Endocrinol & Metab, Shizuoka, Japan

来源：

CASE REPORTS IN ONCOLOGY | 2024年 / 17卷 / 01期

关键词：

Female-to-male transgender; Breast cancer; Endocrine therapy; MASTECTOMY;

D O I：

10.1159/000536212

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Introduction: Managing breast cancer in female-to-male (FtM) transgender patients is complicated and challenging. Androgens play a crucial role in the development of secondary sexual identity in FtM transgender patients, but their effectiveness in breast cancer remains unclear. Furthermore, the considerations for adjuvant endocrine therapy in this population are highly intricate and warrant thorough discussion. Case Presentation: We describe the case of a 44-year-old FtM transgender diagnosed with breast cancer 3 years after initiating androgen receptor agonist therapy as part of his gender identity transition. After mastectomy, adjuvant endocrine therapy was initiated, consisting of a combination of an aromatase inhibitor and a gonadotropin-releasing hormone agonist, along with a cross-sex hormone. Conclusion: Estradiol levels were significantly reduced, and male-typical levels of sex hormones were attained.

引用

页码：208 / 216

页数：9

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