Ephs in cancer progression: complexity and context-dependent nature in signaling, angiogenesis and immunity

被引：3

作者：

Guo, Xiaoting ^{[1
,3
,4
,5
]}

Yang, Yanyi ^{[6
]}

Tang, Jingqun ^{[1
,2
]}

Xiang, Juanjuan ^{[1
,3
,4
,5
]}

机构：

[1] Cent South Univ, Xiangya Hosp 2, Hunan Key Lab Early Diag & Precise Treatment Lung, Changsha 410013, Hunan, Peoples R China

[2] Cent South Univ, Xiangya Hosp 2, Dept Thorac Surg, Changsha 410013, Hunan, Peoples R China

[3] Cent South Univ, Canc Res Inst, Sch Basic Med Sci, Changsha, Hunan, Peoples R China

[4] Cent South Univ, Xiangya Hosp, NHC Key Lab Carcinogenesis, Changsha, Hunan, Peoples R China

[5] Cent South Univ, Xiangya Hosp, Key Lab Carcinogenesis & Canc Invas Chinese, Minist Educ, Changsha, Hunan, Peoples R China

[6] Cent South Univ, Xiangya Hosp 2, Hlth Management Ctr, Changsha, Hunan, Peoples R China

来源：

CELL COMMUNICATION AND SIGNALING | 2024年 / 22卷 / 01期

关键词：

Eph/ephrin; Vascular; Immune; Tumor; Pain; RECEPTOR TYROSINE KINASE; ENDOTHELIAL-CELL MIGRATION; SMALL INTERFERING RNA; MHC CLASS-I; EPHRIN LIGANDS; LUNG-CANCER; INTUSSUSCEPTIVE ANGIOGENESIS; HEPATOCELLULAR-CARCINOMA; THERAPEUTIC TARGET; TUMOR ANGIOGENESIS;

D O I：

10.1186/s12964-024-01580-3

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Eph receptors constitute the largest family of receptor tyrosine kinases, comprising 14 distinct members classified into two subgroups: EphAs and EphBs.. Despite their essential functions in normal physiological processes, accumulating evidence suggests that the involvement of the Eph family in cancer is characterized by a dual and often contradictory nature. Research indicates that Eph/ephrin bidirectional signaling influences cell-cell communication, subsequently regulating cell migration, adhesion, differentiation and proliferation. The contradictory functionalities may arise from the diversity of Eph signaling pathways and the heterogeneity of different cancer microenvironment. In this review, we aim to discuss the dual role of the Eph receptors in tumor development, attempting to elucidate the paradoxical functionality through an exploration of Eph receptor signaling pathways, angiogenesis, immune responses, and more. Our objective is to provide a comprehensive understanding of the molecular mechanisms underlying tumor development. Additionally, we will explore the evolving landscape of utilizing Eph receptors as potential targets for tumor therapy and diagnostic tools.

引用

页数：24