Prognostic scores in primary biliary cholangitis

被引：1

作者：

Tababi, Ramzi ^{[1
]}

Mrabet, Soumaya ^{[1
]}

Akkari, Imen ^{[1
]}

Harbi, Raida ^{[1
]}

Ben Jazia, Elhem ^{[1
]}

机构：

[1] Farhat Hached Univ Hosp, Dept Gastroenterol, Sousse 4000, Tunisia

来源：

FUTURE SCIENCE OA | 2024年 / 10卷 / 01期

关键词：

predictive scores; primary biliary cholangitis; prognosis; treatment response; ursodeoxycholic acid; URSODEOXYCHOLIC ACID; BIOCHEMICAL RESPONSE; SCORING SYSTEM; CIRRHOSIS;

D O I：

10.2144/fsoa-2023-0203

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Aim: Evaluating prognostic scores' utility in predicting ursodeoxycholic acid (UDCA) biochemical response (BR) and long-term liver-related complications in primary biliary cholangitis (PBC) patients. Patients & methods: This retrospective single-center study included 50 predominantly female PBC patients (median age: 56) on UDCA treatment. BR was defined by Paris II criteria. Liver-related complications during a median 76-month follow-up were assessed. APRI, ALBI, Mayo, GLOBE and UK-PBC scores were calculated. Results: 64% achieved BR, while 40% experienced liver-related complications. All scores showed good BR prediction (concordance statistics: 0.76-0.94) and excellent negative predictive values for 5-year liver complications (concordance statistics: 0.73-0.89). Conclusion: Implementing these scores in clinical practice is encouraged due to their effectiveness in predicting BR- and liver-related events.

引用

页数：12

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