Prognostic scores in primary biliary cholangitis

被引：1
作者：
Tababi, Ramzi [1 ]
Mrabet, Soumaya [1 ]
Akkari, Imen [1 ]
Harbi, Raida [1 ]
Ben Jazia, Elhem [1 ]
机构：
[1] Farhat Hached Univ Hosp, Dept Gastroenterol, Sousse 4000, Tunisia
来源：
FUTURE SCIENCE OA | 2024年 / 10卷 / 01期
关键词：
predictive scores; primary biliary cholangitis; prognosis; treatment response; ursodeoxycholic acid; URSODEOXYCHOLIC ACID; BIOCHEMICAL RESPONSE; SCORING SYSTEM; CIRRHOSIS;
D O I：
10.2144/fsoa-2023-0203
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Aim: Evaluating prognostic scores' utility in predicting ursodeoxycholic acid (UDCA) biochemical response (BR) and long-term liver-related complications in primary biliary cholangitis (PBC) patients. Patients & methods: This retrospective single-center study included 50 predominantly female PBC patients (median age: 56) on UDCA treatment. BR was defined by Paris II criteria. Liver-related complications during a median 76-month follow-up were assessed. APRI, ALBI, Mayo, GLOBE and UK-PBC scores were calculated. Results: 64% achieved BR, while 40% experienced liver-related complications. All scores showed good BR prediction (concordance statistics: 0.76-0.94) and excellent negative predictive values for 5-year liver complications (concordance statistics: 0.73-0.89). Conclusion: Implementing these scores in clinical practice is encouraged due to their effectiveness in predicting BR- and liver-related events.
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页数：12
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