Endoplasmic reticulum stress: bridging inflammation and obesity-associated adipose tissue

被引:13
作者
Ma, Kaile [1 ]
Zhang, Yanjiao [1 ]
Zhao, Jingyi [1 ]
Zhou, Lijuan [1 ]
Li, Min [1 ]
机构
[1] China Acad Chinese Med Sci, Guanganmen Hosp, Inst Metab Dis, Beijing, Peoples R China
来源
FRONTIERS IN IMMUNOLOGY | 2024年 / 15卷
基金
北京市自然科学基金; 中国国家自然科学基金;
关键词
endoplasmic reticulum stress; adipose tissue; obesity; inflammation; metabolic disorder; UNFOLDED PROTEIN RESPONSE; NF-KAPPA-B; ER STRESS; TRANSMEMBRANE PROTEIN; INSULIN-RESISTANCE; ENERGY-BALANCE; LINKS OBESITY; ACTIVATION; ATF6; TRANSCRIPTION;
D O I
10.3389/fimmu.2024.1381227
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Obesity presents a significant global health challenge, increasing the susceptibility to chronic conditions such as diabetes, cardiovascular disease, and hypertension. Within the context of obesity, lipid metabolism, adipose tissue formation, and inflammation are intricately linked to endoplasmic reticulum stress (ERS). ERS modulates metabolism, insulin signaling, inflammation, as well as cell proliferation and death through the unfolded protein response (UPR) pathway. Serving as a crucial nexus, ERS bridges the functionality of adipose tissue and the inflammatory response. In this review, we comprehensively elucidate the mechanisms by which ERS impacts adipose tissue function and inflammation in obesity, aiming to offer insights into targeting ERS for ameliorating metabolic dysregulation in obesity-associated chronic diseases such as hyperlipidemia, hypertension, fatty liver, and type 2 diabetes.
引用
收藏
页数:12
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