Longitudinal immune kinetics of COVID-19 booster versus primary series vaccination: Insight into the annual vaccination strategy

被引：3

作者：

Choi, Min Joo ^{[1
,8
]}

Hyun, Hakjun ^{[2
]}

Heo, Jung Yeon ^{[2
]}

Bin Seo, Yu ^{[3
]}

Noh, Ji Yun ^{[4
,5
]}

Cheong, Hee Jin ^{[4
,5
]}

Kim, Woo Joo ^{[4
,5
]}

Kim, Hwa Jung ^{[6
]}

Choi, Ju-yeon ^{[7
]}

Lee, Young Jae ^{[7
]}

Chung, Eun Joo ^{[7
]}

Kim, Su-Hwan ^{[7
]}

Jeong, Hyeonji ^{[7
]}

Kim, Byoungguk ^{[7
]}

Song, Joon Young ^{[4
,5
,8
]}

机构：

[1] Catholic Kwandong Univ, Coll Med, Int St Marys Hosp, Dept Internal Med, Incheon, South Korea

[2] Ajou Univ, Sch Med, Dept Infect Dis, Suwon 441749, South Korea

[3] Hallym Univ, Coll Med, Dept Internal Med, Div Infect Dis,Kangdong Sacred Heart Hosp, Seoul, South Korea

[4] Korea Univ, Coll Med, Guro Hosp, Seoul, South Korea

[5] Korea Univ, Coll Med, Vaccine Innovat Ctr, Seoul, South Korea

[6] Ulsan Univ, Coll Med, Dept Clin Epidemiol & Biostat, Seoul, South Korea

[7] Natl Inst Infect Dis, Ctr Vaccine Res, Div Vaccine Clin Res, Cheongju, South Korea

[8] Korea Univ, Guro Hosp, Dept Internal Med, Coll Med, 148 Gurodong Ro, Seoul 08308, South Korea

来源：

HELIYON | 2024年 / 10卷 / 05期

关键词：

SARS-CoV-2; COVID-19; vaccines; Longevity; Immunogenicity; Booster shot; MEMORY;

D O I：

10.1016/j.heliyon.2024.e27211

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Background: Data on the durability of booster dose immunity of COVID-19 vaccines are relatively limited. Methods: Immunogenicity was evaluated for up to 9-12 months after the third dose of vaccination in 94 healthy adults. Results: Following the third dose, the anti-spike immunoglobulin G (IgG) antibody response against the wild-type was boosted markedly, which decreased gradually over time. However, even 9-12 months after the booster dose, both the median and geometric mean of anti-spike IgG antibody levels were higher than those measured 4 weeks after the second dose. Breakthrough infection during the Omicron-dominant period boosted neutralizing antibody titers against Omicron sublineages (BA.1 and BA.5) and the ancestral strain. T-cell immune response was efficiently induced and maintained during the study period. Conclusions: mRNA vaccine booster dose elicited durable humoral immunity for up to 1 year after the third dose and T-cell immunity was sustained during the study period, supporting an annual COVID-19 vaccination strategy.

引用

页数：9

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