The intersection of homologous recombination (HR) and mismatch repair (MMR) pathways in DNA repair-defective tumors

被引：8

作者：

Incorvaia, Lorena ^{[1
]}

Bazan Russo, Tancredi Didier ^{[1
]}

Gristina, Valerio ^{[1
]}

Perez, Alessandro ^{[1
]}

Brando, Chiara ^{[1
]}

Mujacic, Clarissa ^{[1
]}

Di Giovanni, Emilia ^{[1
]}

Bono, Marco ^{[1
]}

Contino, Silvia ^{[1
]}

Ferrante Bannera, Carla ^{[1
]}

Vitale, Maria Concetta ^{[1
]}

Gottardo, Andrea ^{[1
]}

Peri, Marta ^{[1
]}

Galvano, Antonio ^{[1
]}

Fanale, Daniele ^{[1
]}

Badalamenti, Giuseppe ^{[1
]}

Russo, Antonio ^{[1
]}

Bazan, Viviana ^{[2
]}

机构：

[1] Univ Palermo, Dept Precis Med Med Surg & Crit Care Me Pre CC, Sect Med Oncol, Palermo, Italy

[2] Univ Palermo, Dept Biomed Neurosci & Adv Diagnost BIND, Sect Med Oncol, Palermo, Italy

来源：

NPJ PRECISION ONCOLOGY | 2024年 / 8卷 / 01期

关键词：

RIBOSE POLYMERASE INHIBITORS; MICROSATELLITE INSTABILITY; LYNCH-SYNDROME; OPEN-LABEL; CANCER; OVARIAN; DEFICIENCY; PREDISPOSITION; MUTATION; GENES;

D O I：

10.1038/s41698-024-00672-0

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Homologous recombination (HR) and mismatch repair (MMR) defects are driver mutational imprints and actionable biomarkers in DNA repair-defective tumors. Although usually thought as mutually exclusive pathways, recent preclinical and clinical research provide preliminary evidence of a functional crosslink and crosstalk between HRR and MMR. Shared core proteins are identified as key players in both pathways, broadening the concept of DNA repair mechanism exclusivity in specific tumor types. These observations may result in unexplored forms of synthetic lethality or hypermutable tumor phenotypes, potentially impacting the cancer risk management, and considerably expanding in the future the therapeutic window for DNA repair-defective tumors.

引用

页数：12

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