The Effect of Antipsychotics on Cognition in Schizophrenia-A Current Narrative Review

被引：2

作者：

Lungu, Petru Fabian ^{[1
]}

Lungu, Corina Miruna ^{[2
]}

Ciobica, Alin ^{[1
,3
,4
,5
]}

Balmus, Ioana Miruna ^{[6
,7
]}

Vitalaru, Raluca ^{[8
]}

Mavroudis, Ioannis ^{[9
]}

Dobrin, Romeo ^{[8
,10
]}

Cimpeanu, Mirela ^{[1
]}

Gurzu, Irina Luciana ^{[10
]}

机构：

[1] Alexandru Ioan Cuza Univ, Fac Biol, Biol Dept, Iasi 700506, Romania

[2] Alexandru Ioan Cuza Univ, Fac Psychol & Educ Sci, Psychol Dept, Iasi 700506, Romania

[3] Romanian Acad, Ctr Biomed Res, Iasi Branch, Teodor Codrescu 2, Iasi 700481, Romania

[4] Acad Romanian Sci, 3 Ilfov, Bucharest 050044, Romania

[5] Apollonia Univ, Preclin Dept, Str Pacurari 11, Iasi 700511, Romania

[6] Alexandru Ioan Cuza Univ, Inst Interdisciplinary Res, Dept Exact Sci & Nat Sci, Iasi 700506, Romania

[7] Grigore T Popa Univ Med & Pharm Iasi, CENEMED Platform Interdisciplinary Res, 16th Univ St, Iasi 700115, Romania

[8] Inst Psychiat Socola, Iasi Str Bucium 36, Iasi 700282, Romania

[9] Leeds Teaching Hosp, Dept Neurosci, NHS Trust, Leeds LS2 9JT, England

[10] Grigore T Popa Univ Med & Pharm Iasi, Fac Med, Iasi 700115, Romania

来源：

BRAIN SCIENCES | 2024年 / 14卷 / 04期

关键词：

schizophrenia; antipsychotics; cognition; DOPAMINE-D-2 RECEPTOR OCCUPANCY; RANDOMIZED CONTROLLED-TRIAL; SPATIAL WORKING-MEMORY; QUALITY-OF-LIFE; ATYPICAL ANTIPSYCHOTICS; RATING-SCALE; SEROTONIN RECEPTORS; GLOBAL ASSESSMENT; OLANZAPINE; RISPERIDONE;

D O I：

10.3390/brainsci14040359

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The majority of schizophrenia-affected individuals display deficiencies in multiple cognitive domains such as attention, working memory, long-term memory, and learning, deficiencies that are stable throughout the disease. The purpose of this narrative review was to examine the effect of antipsychotics on several cognitive domains affected by schizophrenia. Methods: We searched MEDLINE, Elsevier, Scopus, and DOAJ databases for randomized controlled trials and other studies investigating the effects of typical and atypical antipsychotics on cognition in patients with schizophrenia in studies conducted in the last decade. Results: The majority of studies included in this review showed that antipsychotics (especially SGAs) have positive effects on both cognition and general psychopathology of schizophrenia. We mention that treatment with antipsychotic substances represents an ongoing effort of the researchers, who are constantly searching for the best approach to meet the mental health needs of schizophrenia patients. Conclusions: Even with those positive results, it should be noted that more studies are needed in order to fully observe the various effects of certain antipsychotic substances on cognition.

引用

页数：25

共 144 条

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