Exploring the detailed role of interleukins in cancer: A comprehensive review of literature

被引:0
|
作者
Saleh, Raed Obaid [1 ]
Jasim, Saade Abdalkareem [2 ,3 ]
Kadhum, Wesam R. [4 ,5 ]
Hjazi, Ahmed [6 ]
Faraz, Ali [7 ]
Abid, Mohammed Kadhem [8 ]
Yumashev, Alexey [9 ]
Alawadi, Ahmed [10 ,11 ,12 ]
Aiad, Ibrahim Ahmed Zaki [13 ]
Alsalamy, Ali [14 ]
机构
[1] Al Maarif Univ Coll, Dept Med Lab Tech, Al Anbar, Iraq
[2] Al Huda Univ Coll, Pharm Dept, Anbar, Iraq
[3] Fallujah Univ, Coll Appl Sci, Biotechnol Dept, Anbar, Iraq
[4] Kut Univ Coll, Dept Pharm, Kut 52001, Wasit, Iraq
[5] Kut Univ Coll, Adv Res Ctr, Kut 52001, Wasit, Iraq
[6] Prince Sattam Bin Abdulaziz Univ, Coll Appl Med Sci, Dept Med Lab, Al Kharj 11942, Saudi Arabia
[7] Majmaah Univ, Coll Med, Dept Basic Med Sci, Majmaah 11952, Saudi Arabia
[8] Al Ayen Univ, Coll Hlth & Med Technol, Dept Anesthesia, Thi Qar, Iraq
[9] Sechenov First Moscow State Med Univ, Dept Prosthet Dent, Moscow, Russia
[10] Islamic Univ, Coll Tech Engn, Najaf, Iraq
[11] Islamic Univ Al Diwaniyah, Coll Tech Engn, Al Diwaniyah, Iraq
[12] Islamic Univ, Coll Tech Engn, Babylon, Iraq
[13] Batterjee Med Coll, Dept Pediat, Gen Med Practice Program, Jeddah 21442, Saudi Arabia
[14] Imam Jaafar Al Sadiq Univ, Coll Tech Engn, Al Muthanna 66002, Iraq
关键词
Cancer; LncRNAs; Interleukins; ICIs; LONG NONCODING RNA; HIGH-DOSE INTERLEUKIN-2; INFLAMMATION; CELLS; IMMUNOTHERAPY; MANAGEMENT; CYTOKINES; RESPONSES; MELANOMA; INSIGHTS;
D O I
10.1016/j.prp.2024.155284
中图分类号
R36 [病理学];
学科分类号
100104 ;
摘要
The cancer cells that are not normal can grow into tumors, invade surrounding tissues, and travel to other parts of the body via the lymphatic or circulatory systems. Interleukins, a vital class of signaling proteins, facilitate cell -to -cell contact within the immune system. A type of non -coding RNA known as lncRNAs mediates its actions by regulating miRNA-mRNA roles (Interleukins). Because of their dual function in controlling the growth of tumors and altering the immune system ' s response to cancer cells, interleukins have been extensively studied concerning cancer. Understanding the complex relationships between interleukins, the immune system, the tumor microenvironment, and the components of interleukin signaling pathways that impact the miRNA-mRNA axis, including lncRNAs, has advanced significantly in cancer research. Due to the significant and allencompassing influence of interleukins on the immune system and the development and advancement of cancers, lncRNAs play a crucial role in cancer research by modulating interleukins. Their diverse effects on immune system regulation, tumor growth encouragement, and tumor inhibition make them appealing candidates for potential cancer treatments and diagnostics. A deeper understanding of the relationship between the biology of interleukin and lncRNAs will likely result in more effective immunotherapy strategies and individualized cancer treatments.
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页数:14
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