Phenolic Extract from Sonchus oleraceus L. Protects Diabetes-related Liver Injury in Rats through TLR4/NF-κB Signaling Pathway

被引：12

作者：

Chen, Lei ^{[1
]}

Fan, Xiaoyun ^{[1
]}

Lin, Xiujun ^{[1
]}

Qian, Liu ^{[1
]}

Zengin, Gokhan ^{[2
]}

Delmas, Dominique ^{[3
]}

Paoli, Paolo ^{[4
]}

Teng, Hui ^{[1
]}

Xiao, Jianbo ^{[5
]}

机构：

[1] Fujian Agr & Forestry Univ, Coll Food Sci, Fuzhou 350002, Peoples R China

[2] Selcuk Univ, Fac Sci, Dept Biol, Konya, Turkey

[3] Univ Bourgogne, Res Ctr, INSERM, U866, Dijon, France

[4] Univ Florence, Dept Biomed Expt & Clin Sci, Florence, Italy

[5] Univ Macau, State Key Lab Qual Res Chinese Med, Inst Chinese Med Sci, Taipa, Macao, Peoples R China

来源：

EFOOD | 2020年 / 1卷 / 01期

基金：

中国博士后科学基金;

关键词：

Anti-inflammation; in vivo; Sonchus oleraceus; liver injury; NF-kappa B signaling pathway; ANTIOXIDANT ACTIVITIES; STREPTOZOTOCIN; OBESITY; CELLS;

D O I：

10.2991/efood.k.191018.002

中图分类号：

TS2 [食品工业];

学科分类号：

0832 ;

摘要：

Sonchus oleraceus Linn. is of great interest in scientific platform because it exhibits significant biological activities. This study investigated the liver protective effects and mechanism of phenolic extract from S. oleraceus (SOL) on Streptozotocin (STZ)-induced diabetic rats. SOL significantly increased both superoxide dismutase activity and glutathione level, while causing a reduction of malondialdehyde level in the liver. Moreover, SOL ameliorates STZ-induced liver function and pathological damages. Diabetic rats fed with S. oleraceus daily for 6 weeks showed significantly decreased levels of tumor necrosis factor alpha and interleukin-1 beta in the liver. Sonchus oleraceus decreased the expression levels of MyD88, TGF-beta, and Toll-Like Receptor (TLR)4 in the liver of diabetic rats. In conclusion, SOL possesses anti-inflammatory activity and suppresses the TLR4/nuclear factor kappa B (NF-kappa B) p65 signaling pathway. (c) 2019 International Association of Dietetic Nutrition and Safety. Publishing services by Atlantis Press International B.V. This is an open access article distributed under the CC BY-NC 4.0 license (http://creativecommons.org/licenses/by-nc/4.0/).

引用

页码：77 / 84

页数：8

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