Immunosuppressive regulatory cells in cancer immunotherapy: restrain or modulate?

被引：2

作者：

Wu, Yan ^{[1
,2
]}

Chen, Dongfeng ^{[3
]}

Gao, Yang ^{[3
,4
]}

Xu, Qinggang ^{[3
]}

Zhou, Yang ^{[3
]}

Ni, Zhong ^{[3
]}

Na, Manli ^{[1
,3
,5
]}

机构：

[1] Jiangsu Univ, Affiliated Hosp, Dept Burn & Plast Surg, Zhenjiang 212001, Jiangsu, Peoples R China

[2] Jiangsu Univ, Sch Med, Zhenjiang 212013, Jiangsu, Peoples R China

[3] Jiangsu Univ, Sch Life Sci, Zhenjiang 212013, Jiangsu, Peoples R China

[4] Univ Macau, Inst Chinese Med Sci, State Key Lab Qual Res Chinese Med, Macau 999078, Peoples R China

[5] Jiangsu Univ, Int Genome Ctr, 301 Xuefu Rd, Zhenjiang 212013, Jiangsu, Peoples R China

来源：

HUMAN CELL | 2024年 / 37卷 / 04期

基金：

中国国家自然科学基金;

关键词：

Immunotherapy; Immunoregulatory cells; MDSCs; Tregs; Safety; TNF RECEPTOR 2; T-CELLS; SUPPRESSOR-CELLS; MYELOID CELLS; SELECTIN EXPRESSION; G-CSF; PROMOTES; CARCINOMA; ANTITUMOR; EXPANSION;

D O I：

10.1007/s13577-024-01083-w

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Immunosuppressive regulatory cells (IRCs) play important roles in negatively regulating immune response, and are mainly divided into myeloid-derived suppressor cells (MDSCs) and regulatory T cells (Tregs). Large numbers of preclinical and clinical studies have shown that inhibition or reduction of IRCs could effectively elevate antitumor immune responses. However, several studies also reported that excessive inhibition of IRCs function is one of the main reasons causing the side effects of cancer immunotherapy. Therefore, the reasonable regulation of IRCs is crucial for improving the safety and efficiency of cancer immunotherapy. In this review, we summarised the recent research advances in the cancer immunotherapy by regulating the proportion of IRCs, and discussed the roles of IRCs in regulating tumour immune evasion and drug resistance to immunotherapies. Furthermore, we also discussed how to balance the potential opportunities and challenges of using IRCs to improve the safety of cancer immunotherapies.

引用

页码：931 / 943

页数：13

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