Unmet needs of biochemical biomarkers for human prion diseases

被引：0

作者：

Hermann, Peter ^{[1
]}

Zerr, Inga ^{[1
,2
]}

机构：

[1] Univ Med Ctr Gottingen, Dept Neurol, Robert Koch Str 40, D-37075 Gottingen, Lower Saxony, Germany

[2] German Ctr Neurodegenerat Dis, Gottingen, Germany

来源：

PRION | 2024年 / 18卷 / 01期

关键词：

Biomarkers; cerebrospinal fluid biomarkers; Creutzfeldt-Jakob disease; diagnosis; disease onset; prion diseases; CREUTZFELDT-JAKOB-DISEASE; CEREBROSPINAL-FLUID; DIAGNOSIS; PROTEIN; ABNORMALITIES; CSF;

D O I：

10.1080/19336896.2024.2349017

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Although the development of aggregation assays has noticeably improved the accuracy of the clinical diagnosis of prion diseases, research on biomarkers remains vital. The major challenges to overcome are non-invasive sampling and the exploration of new biomarkers that may predict the onset or reflect disease progression. This will become extremely important in the near future, when new therapeutics are clinically evaluated and eventually become available for treatment. This article aims to provide an overview of the achievements of biomarker research in human prion diseases, addresses unmet needs in the field, and points out future perspectives.

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页码：89 / 93

页数：5

相关论文

共 38 条

[1] Comparison between plasma and cerebrospinal fluid biomarkers for the early diagnosis and association with survival in prion disease [J].

Abu-Rumeileh, Samir ;

Baiardi, Simone ;

Ladogana, Anna ;

Zenesini, Corrado ;

Bartoletti-Stella, Anna ;

Poleggi, Anna ;

Mammana, Angela ;

Polischi, Barbara ;

Pocchiari, Maurizio ;

Capellari, Sabina ;

Parchi, Piero .

JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY, 2020, 91 (11) :1181-1188

[2] Magnetic resonance imaging findings in pre-clinical Creutzfeldt-Jakob disease [J].

Alvarez, FJ ;

Bisbe, J ;

Bisbe, V ;

Dávalos, A .

INTERNATIONAL JOURNAL OF NEUROSCIENCE, 2005, 115 (08) :1219-1225

[3] Ultrasensitive human prion detection in cerebrospinal fluid by real-time quaking-induced conversion [J].

Atarashi, Ryuichiro ;

Satoh, Katsuya ;

Sano, Kazunori ;

Fuse, Takayuki ;

Yamaguchi, Naohiro ;

Ishibashi, Daisuke ;

Matsubara, Takehiro ;

Nakagaki, Takehiro ;

Yamanaka, Hitoki ;

Shirabe, Susumu ;

Yamada, Masahito ;

Mizusawa, Hidehiro ;

Kitamoto, Tetsuyuki ;

Klug, Genevieve ;

McGlade, Amelia ;

Collins, Steven J. ;

Nishida, Noriyuki .

NATURE MEDICINE, 2011, 17 (02) :175-178

[4] ABNORMAL PROTEINS IN THE CEREBROSPINAL-FLUID OF PATIENTS WITH CREUTZFELDT-JAKOB DISEASE [J].

HARRINGTON, MG ;

MERRIL, CR ;

ASHER, DM ;

GAJDUSEK, DC .

NEW ENGLAND JOURNAL OF MEDICINE, 1986, 315 (05) :279-383

[5] Plasma neurofilament light chain as a biomarker for fatal familial insomnia [J].

Hermann, Peter ;

Canaslan, Sezgi ;

Villar-Pique, Anna ;

Bunck, Timothy ;

Goebel, Stefan ;

Llorens, Franc ;

Schmitz, Matthias ;

Zerr, Inga .

EUROPEAN JOURNAL OF NEUROLOGY, 2022, 29 (06) :1841-1846

[6] Biomarkers and diagnostic guidelines for sporadic Creutzfeldt-Jakob disease [J].

Hermann, Peter ;

Appleby, Brian ;

Brandel, Jean-Philippe ;

Caughey, Byron ;

Collins, Steven ;

Geschwind, Michael D. ;

Green, Alison ;

Haik, Stephane ;

Kovacs, Gabor G. ;

Ladogana, Anna ;

Llorens, Franc ;

Mead, Simon ;

Nishida, Noriyuki ;

Pal, Suvankar ;

Parchi, Piero ;

Pocchiari, Maurizio ;

Satoh, Katsuya ;

Zanusso, Gianluigi ;

Zerr, Inga .

LANCET NEUROLOGY, 2021, 20 (03) :235-246

[7] Validation and utilization of amended diagnostic criteria in Creutzfeldt-Jakob disease surveillance [J].

Hermann, Peter ;

Laux, Mareike ;

Glatzel, Markus ;

Matschke, Jakob ;

Knipper, Tobias ;

Goebel, Stefan ;

Treig, Johannes ;

Schulz-Schaeffer, Walter ;

Cramm, Maria ;

Schmitz, Matthias ;

Zerr, Inga .

NEUROLOGY, 2018, 91 (04) :E331-E338

[8] The 14-3-3 brain protein in cerebrospinal fluid as a marker for transmissible spongiform encephalopathies [J].

Hsich, G ;

Kinney, K ;

Gibbs, CJ ;

Lee, KH ;

Harrington, MG .

NEW ENGLAND JOURNAL OF MEDICINE, 1996, 335 (13) :924-930

[9] Detection of α-synuclein in CSF by RT-QuIC in patients with isolated rapid-eye-movement sleep behaviour disorder: a longitudinal observational study [J].

Iranzo, Alex ;

Fairfoul, Graham ;

Ayudhaya, Anutra Chumbala Na ;

Serradell, Monica ;

Gelpi, Ellen ;

Vilaseca, Isabel ;

Sanchez-Valle, Raquel ;

Gaig, Carles ;

Santamaria, Joan ;

Tolosa, Eduard ;

Riha, Renata L. ;

Green, Alison J. E. .

LANCET NEUROLOGY, 2021, 20 (03) :203-212

[10] Case Report: Extremely Early Detection of Preclinical Magnetic Resonance Imaging Abnormality in Creutzfeldt-Jakob Disease With the V180I Mutation [J].

Koizumi, Ryuichi ;

Ueda, Naohisa ;

Mugita, Atsushi ;

Kimura, Katsuo ;

Kishida, Hitaru ;

Tanaka, Fumiaki .

FRONTIERS IN NEUROLOGY, 2021, 12

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