Peptide-Based Inhibitors of the Induced Signaling Protein Interactions: Current State and Prospects

被引：1

作者：

Toshchakov, Vladimir Y. ^{[1
]}

机构：

[1] Sirius Univ Sci & Technol, Sirius Fed Terr 354340, Krasnodar Krai, Russia

来源：

BIOCHEMISTRY-MOSCOW | 2024年 / 89卷 / 05期

关键词：

Toll-like receptors; TIR domains; signaling complexes; peptide inhibitors of protein interactions; CELL-PENETRATING PEPTIDES; NF-KAPPA-B; HIGHER-ORDER ASSEMBLIES; DECOY PEPTIDES; VACCINIA VIRUS; ADAPTER-LIKE; ANTIMICROBIAL PEPTIDES; DOMAIN DIMERIZATION; STRUCTURAL BASIS; TAT PROTEIN;

D O I：

10.1134/S000629792405002X

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Formation of the transient protein complexes in response to activation of cellular receptors is a common mechanism by which cells respond to external stimuli. This article presents the concept of blocking interactions of signaling proteins by the peptide inhibitors, and describes the progress achieved to date in the development of signaling inhibitors that act by blocking the signal-dependent protein interactions.

引用

页码：784 / 798

页数：15

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