Causal associations between autoimmune diseases and sarcopenia-related traits: a bi-directional Mendelian randomization study

被引:2
作者
Chen, Chunlan [1 ]
He, Ying [2 ,3 ]
机构
[1] Southern Med Univ, Guangdong Prov Peoples Hosp, Guangdong Acad Med Sci, Dept Pulm & Crit Care Med, Guangzhou, Peoples R China
[2] Cent South Univ, Xiangya Hosp 2, Dept Infect Dis, Changsha, Peoples R China
[3] Clin Med Res Ctr Viral Hepatitis Hunan Prov, Changsha, Peoples R China
基金
中国国家自然科学基金;
关键词
autoimmune diseases; sarcopenia; causal association; Mendelian randomization; genome-wide association studies; INFLAMMATORY-BOWEL-DISEASE; RHEUMATOID-ARTHRITIS; BODY-COMPOSITION; SUSCEPTIBILITY; PREVALENCE; RISK; LOCI;
D O I
10.3389/fgene.2024.1325058
中图分类号
Q3 [遗传学];
学科分类号
071007 ; 090102 ;
摘要
Background: Sarcopenia is common in patients with autoimmune diseases (ADs); however, the causal associations between ADs and sarcopenia remain unclear. Therefore, this study investigated the causal associations using bi-directional Mendelian randomization analysis.Methods: Exposure-related single-nucleotide polymorphisms (SNPs) were extracted from genome-wide association studies (GWASs). GWAS statistics for common ADs [Crohn's disease (CD), ulcerative colitis (UC), rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), psoriasis (PSO), and multiple sclerosis (MS)] and sarcopenia-related traits [hand grip strength (HGS), appendicular fat-free mass (FFM), and walking pace] were obtained from public datasets. Inverse-variance weighting as the main method was used to evaluate the causal effect.Results: Genetically predicted CD had causal effects on whole-body FFM (beta = -0.005, p = 0.001), leg FFM (beta left = -0.006, p = 1.8E-4; beta right = -0.007, p = 2.0E-4), and arm FFM (beta left = -0.005, p = 0.005; beta right = -0.005, p = 0.001), while RA had causal effects on 8 sarcopenia-related traits, namely, HGS (beta left = -2.06, p = 2.8E-38; beta right = -2.311, p = 2E-20), whole-body FFM (beta = -0.842, p = 4.7E-10), leg FFM (beta left = -0.666, p = 2.6E-6; beta right = -0.073, p = 2.1E-3), arm FFM (beta left = -0.63, p = 4.4E-6; beta right = -0.736, p = 4.4E-8), and walking pace (beta = -1.019, p = 6.2E-14). In the reverse direction, HGS (odds ratio [OR]left = 10.257, p = 3.6E-5; ORright = 16.445, p = 3.7E-7) had causal effects on CD, while HGS (ORleft = 0.994, p = 0.004; ORright = 0.993, p = 1.4E-4), leg FFM (ORleft = 1.003, p = 0.005; ORright = 1.005, p = 1.9E-4), and walking pace (OR = 0.985, p = 5.7E-5) were causally associated with RA. No evidence showed causal associations of UC, SLE, PSO, or MS with sarcopenia-related traits.Conclusion: Our study demonstrated that the genetic susceptibility to CD and RA was associated with high risk of sarcopenia, and some sarcopenia-related traits had causal effects on CD or RA.
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页数:11
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