Infant Acute Lymphoblastic Leukemia-New Therapeutic Opportunities

被引：2

作者：

Kulczycka, Marika ^{[1
]}

Derlatka, Kamila ^{[1
]}

Tasior, Justyna ^{[1
]}

Sygacz, Maja ^{[1
]}

Lejman, Monika ^{[2
]}

Zawitkowska, Joanna ^{[3
]}

机构：

[1] Med Univ Lublin, Dept Pediat Hematol Oncol & Transplantol, Student Sci Soc, PL-20093 Lublin, Poland

[2] Med Univ Lublin, Independent Lab Genet Diagnost, PL-20093 Lublin, Poland

[3] Med Univ Lublin, Dept Pediat Hematol Oncol & Transplantol, PL-20093 Lublin, Poland

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2024年 / 25卷 / 07期

关键词：

acute lymphoblastic leukemia; infant; targeted therapies; STEM-CELL TRANSPLANTATION; MINIMAL RESIDUAL DISEASE; YOUNG-ADULTS; PEDIATRIC-PATIENTS; BLINATUMOMAB; CHEMOTHERAPY; REARRANGEMENTS; CHILDREN; MENIN; INTERFANT-99;

D O I：

10.3390/ijms25073721

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Infant acute lymphoblastic leukemia (Infant ALL) is a kind of pediatric ALL, diagnosed in children under 1 year of age and accounts for less than 5% of pediatric ALL. In the infant ALL group, two subtypes can be distinguished: KMT2A-rearranged ALL, known as a more difficult to cure form and KMT2A- non-rearranged ALL with better survival outcomes. As infants with ALL have lesser treatment outcomes compared to older children, it is pivotal to provide novel treatment approaches. Progress in the development of molecularly targeted therapies and immunotherapy presents exciting opportunities for potential improvement. This comprehensive review synthesizes the current literature on the epidemiology, clinical presentation, molecular genetics, and therapeutic approaches specific to ALL in the infant population.

引用

页数：14

共 74 条

[1] The landscape of somatic mutations in infant MLL-rearranged acute lymphoblastic leukemias
Andersson, Anna K.
Ma, Jing
Wang, Jianmin
Chen, Xiang
Gedman, Amanda Larson
Dang, Jinjun
Nakitandwe, Joy
Holmfeldt, Linda
Parker, Matthew
Easton, John
Huether, Robert
Kriwacki, Richard
Rusch, Michael
Wu, Gang
Li, Yongjin
Mulder, Heather
Raimondi, Susana
Pounds, Stanley
Kang, Guolian
Shi, Lei
Becksfort, Jared
Gupta, Pankaj
Payne-Turner, Debbie
Vadodaria, Bhavin
Boggs, Kristy
Yergeau, Donald
Manne, Jayanthi
Song, Guangchun
Edmonson, Michael
Nagahawatte, Panduka
Wei, Lei
Cheng, Cheng
Pei, Deqing
Sutton, Rosemary
Venn, Nicola C.
Chetcuti, Albert
Rush, Amanda
Catchpoole, Daniel
Heldrup, Jesper
Fioretos, Thoas
Lu, Charles
Ding, Li
Pui, Ching-Hon
Shurtleff, Sheila
Mullighan, Charles G.
Mardis, Elaine R.
Wilson, Richard K.
Gruber, Tanja A.
Zhang, Jinghui
Downing, James R.
[J]. NATURE GENETICS, 2015, 47 (04) : 330 - U192
[2] Clinical Experience of CAR T Cell Immunotherapy for Relapsed and Refractory Infant ALL Demonstrates Feasibility and Favorable Responses
Annesley, Colleen
Summers, Corinne
Pulsipher, Michael A.
Wayne, Alan S.
Rivers, Julie
Lamble, Adam J.
Wilson, Ashley
Wu, Qian Vicky
Brand, Adam
Mgebroff, Stephanie
Brown, Christopher
Lindgren, Catherine
Park, Julie R.
Jensen, Michael C.
Gardner, Rebecca
[J]. BLOOD, 2019, 134
[3] Mixed lineage leukemia-rearranged childhood pro-B and CD10-negative pre-B acute lymphoblastic leukemia constitute a distinct clinical entity
Attarbaschi, Andishe
Mann, Georg
Koenig, Margit
Steiner, Manuel
Strehl, Sabine
Schreiberhuber, Anita
Schneider, Bjoern
Meyer, Claus
Marschalek, Rolf
Borkhardt, Arndt
Pickl, Winfried F.
Lion, Thomas
Gadner, Helmut
Haas, Oskar A.
Dworzak, Michael N.
[J]. CLINICAL CANCER RESEARCH, 2006, 12 (10) : 2988 - 2994
[4] Favorable outcome of NUTM1-rearranged infant and pediatric B cell precursor acute lymphoblastic leukemia in a collaborative international study
Boer, Judith M.
Valsecchi, Maria Grazia
Hormann, Femke M.
Antic, Zeljko
Zaliova, Marketa
Schwab, Claire
Cazzaniga, Giovanni
Arfeuille, Chloe
Cave, Helene
Attarbaschi, Andishe
Strehl, Sabine
Escherich, Gabriele
Imamura, Toshihiko
Ohki, Kentaro
Grueber, Tanja A.
Sutton, Rosemary
Pastorczak, Agata
Lammens, Tim
Lambert, Frederic
Li, Chi Kong
Carrillo de Santa Pau, Enrique
Hoffmann, Steve
Moericke, Anja
Harrison, Christine J.
Den Boer, Monique L.
De Lorenzo, Paola
Stam, Ronald W.
Bergmann, Anke K.
Pieters, Rob
[J]. LEUKEMIA, 2021, 35 (10) : 2978 - 2982
[5] The molecular landscape of pediatric acute myeloid leukemia reveals recurrent structural alterations and age-specific mutational interactions
Bolouri, Hamid
Farrar, Jason E.
Triche, Timothy, Jr.
Ries, Rhonda E.
Lim, Emilia L.
Alonzo, Todd A.
Ma, Yussanne
Moore, Richard
Mungall, Andrew J.
Marra, Marco A.
Zhang, Jinghui
Ma, Xiaotu
Liu, Yu
Liu, Yanling
Auvil, Jaime M. Guidry
Davidsen, Tanja M.
Gesuwan, Patee
Hermida, Leandro C.
Salhia, Bodour
Capone, Stephen
Ramsingh, Giridharan
Zwaan, Christian Michel
Noort, Sanne
Piccolo, Stephen R.
Kolb, E. Anders
Gamis, Alan S.
Smith, Malcolm A.
Gerhard, Daniela S.
Meshinchi, Soheil
[J]. NATURE MEDICINE, 2018, 24 (01) : 103 - +
[6] Use of CD19-directed CAR T-Cell Therapy in an Infant With Refractory Acute Lymphoblastic Leukemia
Breese, Erin H.
Krupski, Christa
Nelson, Adam S.
Perentesis, John P.
Phillips, Christine L.
[J]. JOURNAL OF PEDIATRIC HEMATOLOGY ONCOLOGY, 2021, 43 (04) : 152 - 154
[7] How I treat infant leukemia
Brown, Patrick
Pieters, Rob
Biondi, Andrea
[J]. BLOOD, 2019, 133 (03) : 205 - 214
[8] Treatment of infant leukemias: challenge and promise
Brown, Patrick
[J]. HEMATOLOGY-AMERICAN SOCIETY OF HEMATOLOGY EDUCATION PROGRAM, 2013, : 596 - 600
[9] FLT3 inhibitor lestaurtinib plus chemotherapy for newly diagnosed KMT2A-rearranged infant acute lymphoblastic leukemia: Children's Oncology Group trial AALL0631
Brown, Patrick A.
Kairalla, John A.
Hilden, Joanne M.
Dreyer, ZoAnn E.
Carroll, Andrew J.
Heerema, Nyla A.
Wang, Cindy
Devidas, Meenakshi
Gore, Lia
Salzer, Wanda L.
Winick, Naomi J.
Carroll, William L.
Raetz, Elizabeth A.
Borowitz, Michael J.
Small, Donald
Loh, Mignon L.
Hunger, Stephen P.
[J]. LEUKEMIA, 2021, 35 (05) : 1279 - 1290
[10] Interaction of MLL amino terminal sequences with menin is required for transformation
Caslini, Corrado
Yang, Zhaohai
El-Osta, Mohamad
Milne, Thomas A.
Slany, Robeft K.
Hess, Jay L.
[J]. CANCER RESEARCH, 2007, 67 (15) : 7275 - 7283

← 1 2 3 4 5 6 7 8 →