Prognostic factors for disease activity in newly diagnosed teriflunomide-treated patients with multiple sclerosis: a nationwide Danish study

被引：0

作者：

Mahler, Mie Reith ^{[1
,15
]}

Magyari, Melinda ^{[1
,2
]}

Pontieri, Luigi ^{[1
]}

Elberling, Frederik ^{[1
]}

Holm, Rolf Pringler ^{[1
]}

Weglewski, Arkadiusz ^{[2
,3
]}

Poulsen, Mai Bang ^{[4
]}

Storr, Lars Kristian ^{[5
]}

Bekyarov, Plamen Anzhelov ^{[6
]}

Illes, Zsolt ^{[7
]}

Kant, Matthias ^{[8
]}

Sejbaek, Tobias ^{[9
,10
]}

Stilund, Morten Leif ^{[11
]}

Rasmussen, Peter, V ^{[12
]}

Brask, Maria ^{[13
]}

Urbonaviciute, Inga ^{[14
]}

Sellebjerg, Finn ^{[1
,2
]}

机构：

[1] Copenhagen Univ Hosp, Danish Multiple Sclerosis Registry, Danish Multiple Sclerosis Res Ctr, Glostrup, Denmark

[2] Univ Copenhagen, Fac Hlth & Med Sci, Dept Clin Med, Copenhagen, Denmark

[3] Herlev Hosp, Dept Neurol, Herlev, Denmark

[4] Nordsjaellands Hosp, Dept Neurol, Hillerod, Denmark

[5] Zealand Univ Hosp, Dept Neurol, Roskilde, Denmark

[6] Slagelse Hosp, Dept Neurol, Slagelse, Denmark

[7] Odense Univ Hosp, Dept Neurol, Odense, Denmark

[8] Hosp Southern Jutland Soenderborg Branch, Dept Neurol, Sonderborg, Denmark

[9] Esbjerg Cent Hosp, Dept Pathol, Esbjerg, Denmark

[10] Univ Southern Denmark, Dept Reg Hlth Res, Odense, Denmark

[11] Goedstrup Hosp, Dept Neurol Physiotherapy & Occupat Therapy, Herning, Denmark

[12] Aarhus Univ Hosp, Dept Neurol, Aarhus, Denmark

[13] Viborg Reg Hosp, Dept Neurol, Viborg, Denmark

[14] Aalborg Univ Hosp, Dept Neurol, Aalborg, Denmark

[15] Copenhagen Univ Hosp, Danish Multiple Sclerosis Res Ctr, Danish Multiple Sclerosis Registry, DK-2600 Glostrup, Denmark

来源：

JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY | 2024年 / 95卷 / 10期

关键词：

MULTIPLE SCLEROSIS; EVIDENCE-BASED NEUROLOGY; NEUROEPIDEMIOLOGY; ORAL MEDICINE; STATISTICS; PREDICTION; AGE; ENHANCEMENT; THERAPY;

D O I：

10.1136/jnnp-2023-333265

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Background Clinicians frequently rely on relapse counts, T2 MRI lesion load (T2L) and Expanded Disability Status Scale (EDSS) scores to guide treatment decisions for individuals diagnosed with multiple sclerosis (MS). This study evaluates how these factors, along with age and sex, influence prognosis during treatment with teriflunomide (TFL).Methods We conducted a nationwide cohort study using data from the Danish Multiple Sclerosis Registry. Eligible participants had relapsing-remitting MS or clinically isolated syndrome and initiated TFL as their first treatment between 2013 and 2019. The effect of age, pretreatment relapses, T2L and EDSS scores on the risk of disease activity on TFL were stratified by sex.Methods We conducted a nationwide cohort study using data from the Danish Multiple Sclerosis Registry. Eligible participants had relapsing-remitting MS or clinically isolated syndrome and initiated TFL as their first treatment between 2013 and 2019. The effect of age, pretreatment relapses, T2L and EDSS scores on the risk of disease activity on TFL were stratified by sex.Results In total, 784 individuals were included (57.4% females). A high number of pretreatment relapses (>= 2) was associated with an increased risk of disease activity in females only (OR and (95% CI): 1.76 (1.11 to 2.81)). Age group 50+ was associated with a lower risk of disease activity in both sexes (OR females=0.28 (0.14 to 0.56); OR males=0.22 (0.09 to 0.55)), while age 35-49 showed a different impact in males and females (OR females=0.79 (0.50 to 1.23); OR males=0.42 (0.24 to 0.72)). EDSS scores and T2L did not show any consistent associations.Conclusion A high number of pretreatment relapses was only associated with an increased risk of disease activity in females, while age had a differential impact on the risk of disease activity according to sex. Clinicians may consider age, sex and relapses when deciding on TFL treatment.

引用

页码：979 / 987

页数：9

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