Harnessing the supremacy of MEG3 LncRNA to defeat gastrointestinal malignancies

被引：9

作者：

Rashwan, H. H. ^{[1
,2
]}

Taher, A. M. ^{[1
]}

Awaji, A. A. ^{[3
]}

Kiriacos, C. J. ^{[1
]}

Assal, R. A. ^{[4
]}

Youness, R. A. ^{[1
,5
]}

机构：

[1] German Int Univ GIU, Fac Biotechnol, Mol Genet & Biochem Dept, Mol Genet Res Team MGRT, Cairo 11835, Egypt

[2] Nile Univ, Ctr Informat Sci CIS, Sch Informat Technol & Comp Sci ITCS, Bioinformat Grp, Giza 12677, Egypt

[3] Univ Coll Taymaa, Univ Tabuk, Fac Sci, Dept Biol, Tabuk 71491, Saudi Arabia

[4] Heliopolis Univ Sustainable Dev, Fac Pharm, Dept Pharmacol & Toxicol, Cairo, Egypt

[5] German Int Univ, Fac Biotechnol, Mol Genet Res Team MGRT, Mol Genet & Biochem, Cairo, Egypt

来源：

PATHOLOGY RESEARCH AND PRACTICE | 2024年 / 256卷

关键词：

LncRNA; MEG3; GIT; Cancer; HCC; Colorectal cancer; Pancreatic cancer; Gastric cancer; CCA; GISTs; LONG NONCODING RNA; ENDOPLASMIC-RETICULUM STRESS; PROMOTES CELL-PROLIFERATION; HEPATOCELLULAR-CARCINOMA; GASTRIC-CANCER; ESOPHAGEAL CANCER; UP-REGULATION; COLORECTAL-CANCER; DOWN-REGULATION; LIVER-CANCER;

D O I：

10.1016/j.prp.2024.155223

中图分类号：

R36 [病理学];

学科分类号：

100104 ;

摘要：

Evidence suggests that long non -coding RNAs (lncRNAs) play a pivotal role in the carcinogenesis and progression of various human malignancies including gastrointestinal malignancies. This comprehensive review reports the functions and mechanisms of the lncRNA maternally expressed gene 3 (MEG3) involved in gastrointestinal malignancies. It summarizes its roles in mediating the regulation of cellular proliferation, apoptosis, migration, invasiveness, epithelial-to-mesenchymal transition, and drug resistance in several gastrointestinal cancers such as colorectal cancer, gall bladder cancer, pancreatic cancer, gastric cancer, esophageal cancer, cholangiocarcinoma, gastrointestinal stromal tumors and most importantly, hepatocellular carcinoma. In addition, the authors briefly highlight its implicated mechanistic role and interactions with different non -coding RNAs and oncogenic signaling cascades. This review presents the rationale for developing non coding RNA -based anticancer therapy via harnessing the power of MEG3 in gastrointestinal malignancies.

引用

页数：14

共 276 条

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