Anti-inflammatory Steroids from the South China Sea Sponge Spongia officinalis

被引：0

作者：

Liu, Jiao ^{[1
]}

Liu, Zi-Yi ^{[2
,3
]}

Fu, Yan ^{[3
]}

Gu, Yu-Cheng ^{[4
]}

Li, Song-Wei ^{[1
]}

Zhang, Hai-Yan ^{[2
,3
]}

Guo, Yue-Wei ^{[1
,5
]}

机构：

[1] Shanghai Univ, Sch Med, Shanghai 200444, Peoples R China

[2] Nanchang Univ, Sch Pharmaceut Sci, Nanchang 330006, Peoples R China

[3] Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, 555 Zu Chong Zhi Rd,Zhangjiang Hitech Pk, Shanghai 201203, Peoples R China

[4] Syngenta, Jealotts Hill Int Res Ctr, Bracknell RG42 6EY, Berkshire, England

[5] Bohai Rim Adv Res Inst Drug Discovery, Shandong Lab Yantai Drug Discovery, Yantai 264117, Shandong, Peoples R China

来源：

CHEMISTRY & BIODIVERSITY | 2024年 / 21卷 / 06期

基金：

美国国家科学基金会;

关键词：

Sponge; Spongia officinalis; Chemical investigation; Absolute configuration; Anti-inflammatory activity; DERIVATIVES;

D O I：

10.1002/cbdv.202400519

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

One new highly degraded steroid, namely 21-nor-4-ene-chaxine A (1) furnishing a 5/6/5-tricyclic, along with one known related analogue (2), were isolated from the South China Sea sponge Spongia officinalis. Their structures including absolute configurations were established by extensive spectroscopic data analysis, TDDFT-ECD calculation, and comparison with the spectral data previously reported in the literature. Compound 1 represent the new member of incisterols family with a highly degradation in ring B. In vitro bioassays revealed compound 2 exhibited significant anti-microglial inflammatory effect on lipopolysaccharide (LPS)-induced inflammation in BV-2 microglial cells.

引用

页数：5

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