Recent developments in the diagnosis of pancreatic neuroendocrine neoplasms

被引:0
作者
Battistella, Anna [1 ,2 ]
Tacelli, Matteo [2 ,3 ]
Mapelli, Paola [2 ,4 ]
Schiavo Lena, Marco [5 ]
Andreasi, Valentina [1 ,2 ]
Genova, Luana [1 ,2 ]
Muffatti, Francesca [1 ]
De Cobelli, Francesco [2 ,6 ]
Partelli, Stefano [1 ,2 ]
Falconi, Massimo [1 ,2 ,7 ]
机构
[1] IRCCS San Raffaele Sci Inst, Pancreas Translat & Clin Res Ctr, Pancreat Surg Unit, Milan, Italy
[2] Univ Vita Salute San Raffaele, Milan, Italy
[3] IRCCS San Raffaele Sci Inst, Pancreatobiliary Endoscopy & EUS Div, Milan, Italy
[4] IRCCS San Raffaele Sci Inst, Nucl Med Dept, Milan, Italy
[5] IRCCS San Raffaele Sci Inst, Pathol Unit, Milan, Italy
[6] IRCCS San Raffaele Sci Inst, Radiol Unit, Milan, Italy
[7] Univ Vita Salute San Raffaele, San Raffaele Sci Inst, Pancreas Translat & Clin Res Ctr, Pancreat Surg Unit, Via Olgettina 60, I-20132 Milan, Italy
关键词
PanNENs; diagnostic work-up; biomarkers; radiomics; molecular signatures; CE-EUS; EUS-E; 68Ga]Ga-DOTA-peptide PET; 18F]FDG PET; NETest; ENETS CONSENSUS GUIDELINES; FINE-NEEDLE-ASPIRATION; ENDOSCOPIC ULTRASOUND ELASTOGRAPHY; CT RADIOMIC FEATURES; DYNAMIC ENHANCED CT; CHROMOGRANIN-A; ENDOCRINE TUMORS; DIFFERENTIAL-DIAGNOSIS; TEXTURE ANALYSIS; CONTRAST-ENHANCEMENT;
D O I
10.1080/17474124.2024.2342837
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
IntroductionPancreatic Neuroendocrine Neoplasms (PanNENs) are characterized by a highly heterogeneous clinical and biological behavior, making their diagnosis challenging. PanNENs diagnostic work-up mainly relies on biochemical markers, pathological examination, and imaging evaluation. The latter includes radiological imaging (i.e. computed tomography [CT] and magnetic resonance imaging [MRI]), functional imaging (i.e. 68Gallium [68 Ga]Ga-DOTA-peptide PET/CT and Fluorine-18 fluorodeoxyglucose [18F]FDG PET/CT), and endoscopic ultrasound (EUS) with its associated procedures.Areas coveredThis review provides a comprehensive assessment of the recent advancements in the PanNENs diagnostic field. PubMed and Embase databases were used for the research, performed from inception to October 2023.Expert opinionA deeper understanding of PanNENs biology, recent technological improvements in imaging modalities, as well as progresses achieved in molecular and cytological assays, are fundamental players for the achievement of early diagnosis and enhanced preoperative characterization of PanNENs. A multimodal diagnostic approach is required for a thorough disease assessment.
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收藏
页码:155 / 169
页数:15
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