Polycystic ovary syndrome (PCOS) and genetic predisposition: A review article

被引：171

作者：

Ajmal, Nida ^{[1
]}

Khan, Sanam Zeib ^{[1
]}

Shaikh, Rozeena ^{[1
]}

机构：

[1] Balochistan Univ Informat Technol Engn & Managemen, Fac Life Sci & Informat, Dept Biotechnol, Quetta, Balochistan, Pakistan

来源：

EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY | 2019年 / 3卷

关键词：

Polycystic ovary syndrome; Infertility; Hormonal disbalance; Endocrine reproductive disorder;

D O I：

10.1016/j.eurox.2019.100060

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

Polycystic ovary syndrome (PCOS) is a heterogeneous condition which is related to an endocrine reproductive disorder of females. It affects females of 18-44 age. The persistent hormonal disbalance leads to the complexities such as numerous cysts, an irregular menstrual cycle that ultimately leads to infertility among females. Many candidate genes have been identified to be one of the causes of PCOS. Different studies have been carried out to find the genetic correlation of PCOS. It is essential to carry out such studies that identify the clear cause of PCOS and its genetic association and hormonal disbalance. This review has highlighted different genes and their correlation with PCOS that leads to hormonal disbalance. Yet not in-depth but an attempt to study the genetic predisposition of PCOS.(c) 2019 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY-NC ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

引用

页数：6

共 64 条

[1] A review of the EXIT (EX utero Intrapartum Treatment) procedure [J].

Abraham, R. J. ;

Sau, A. ;

Maxwell, D. .

JOURNAL OF OBSTETRICS AND GYNAECOLOGY, 2010, 30 (01) :1-5

[2] Intrauterine diagnosis and management of congenital goitrous hypothyroidism [J].

Agrawal, P ;

Ogilvy-Stuart, A ;

Lees, C .

ULTRASOUND IN OBSTETRICS & GYNECOLOGY, 2002, 19 (05) :501-505

[3]

Baba K, 2001, St Marianna Med J, V29, P303

[4] Graves' Disease in Two Pregnancies Complicated by Fetal Goitrous Hypothyroidism: Successful In Utero Treatment with Levothyroxine [J].

Blidda, Sofie ;

Rasmussen, Ase Krogh ;

Sundberg, Karin ;

Brocks, Vibeke ;

Skovbo, Peter ;

Feldt-Rasmussen, Ulla .

THYROID, 2011, 21 (01) :75-81

[5] Antithyroid drug-induced fetal goitrous hypothyroidism [J].

Bliddal, Sofie ;

Rasmussen, Ase Krogh ;

Sundberg, Karin ;

Brocks, Vibeke ;

Feldt-Rasmussen, Ulla .

NATURE REVIEWS ENDOCRINOLOGY, 2011, 7 (07) :396-406

[6] Intrauterine therapy of goitrous hypothyroidism in a boy with a new compound heterozygous mutation (Y453D and C800R) in the thyroid peroxidase gene.: A long-term follow-up [J].

Börgel, K ;

Pohlenz, J ;

Holzgreve, W ;

Bramswig, JH .

AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY, 2005, 193 (03) :857-858

[7] Antenatal diagnosis and treatment of fetal hypothyroidism - A report of two cases [J].

Bruner, JP ;

Dellinger, EH .

FETAL DIAGNOSIS AND THERAPY, 1997, 12 (04) :200-204

[8] In utero Fetal Intubation for a Large Neck Mass: A Minimally Invasive EXIT Option [J].

Chmait, Ramen H. ;

Chon, Andrew H. ;

Anselmo, Dean ;

Vanderbilt, Douglas L. ;

Townsend, Jae ;

Julian-Wang, Beth ;

Don, Debra .

FETAL DIAGNOSIS AND THERAPY, 2019, 45 (04) :275-280

[9] Treatment of fetal goitrous hypothyroidism: value of direct intramuscular L-thyroxine therapy [J].

Corral, Edgardo ;

Reascos, Mauricio ;

Preiss, Yudith ;

Rompel, Shanna M. ;

Sepulveda, Waldo .

PRENATAL DIAGNOSIS, 2010, 30 (09) :899-901

[10] Fetal Endoscopic Tracheal Intubation: A New Fetoscopic Procedure to Ensure Extrauterine Tracheal Permeability in a Case with Congenital Cervical Teratoma [J].

Cruz-Martinez, Rogelio ;

Moreno-Alvarez, Oscar ;

Garcia, Maritza ;

Pineda, Hugo ;

Cruz, Miriam A. ;

Martinez-Morales, Cecilia .

FETAL DIAGNOSIS AND THERAPY, 2015, 38 (02) :154-158

← 1 2 3 4 5 6 7 →