RELN gene-related drug-resistant epilepsy with periventricular nodular heterotopia treated with radiofrequency thermocoagulation: a case report

被引：0

作者：

Li, Zijian ^{[1
]}

Wang, Fuli ^{[1
]}

He, Zhidong ^{[2
]}

Guo, Qi ^{[1
]}

Zhang, Jinnan ^{[2
]}

Liu, Songyan ^{[1
]}

机构：

[1] Jilin Univ, China Japan Union Hosp, Dept Neurol, Changchun, Peoples R China

[2] Jilin Univ, China Japan Union Hosp, Dept Neurosurg, Changchun, Peoples R China

来源：

FRONTIERS IN NEUROLOGY | 2024年 / 15卷

关键词：

RELN gene; periventricular nodular heterotopia; radiofrequency thermocoagulation; stereoelectroencephalography; drug-resistant epilepsy; MUTATIONS CAUSE; REELIN; SPECTRUM; MALFORMATIONS;

D O I：

10.3389/fneur.2024.1366776

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

An increasing number of gene mutations associated with epilepsy have been identified, some linked to gray matter heterotopia-a common cause of drug-resistant epilepsy. Current research suggests that gene mutation-associated epilepsy should not be considered a contraindication for surgery in epilepsy patients. At present, stereoelectroencephalography-guided radiofrequency thermocoagulation is an important method to treat periventricular nodular heterotopia-associated drug-resistant epilepsy. We present a case of drug-resistant epilepsy, accompanied by periventricular nodular heterotopia and a heterozygous mutation of the RELN gene, successfully treated with radiofrequency thermocoagulation, resulting in a favorable outcome.

引用

页数：6

共 25 条

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