Asbestos Exposure and Ovarian Cancer: A Meta-analysis

被引：3

作者：

Kim, Seo Young ^{[1
]}

Chang, Ha Kyun ^{[2
,4
]}

Kwon, Ohwi ^{[1
]}

Park, Jaeyoung ^{[1
]}

Myong, Jun-Pyo ^{[1
,3
]}

机构：

[1] Catholic Univ Korea, Seoul St Marys Hosp, Coll Med, Dept Occupat & Environm Med, Seoul, South Korea

[2] Korea Univ, Ansan Hosp, Sch Med, Dept Obstet & Gynecol, Ansan, South Korea

[3] Catholic Univ Korea, Seoul St Marys Hosp, Coll Med, Dept Occupat & Environm Med, 222 Banpo Daero Seocho Gu, Seoul 137701, South Korea

[4] Korea Univ, Ansan Hosp, Dept Obstet & Gynecol, 123 Jeokgeum Ro, Ansan 15355, Gyeonggi Do, South Korea

来源：

SAFETY AND HEALTH AT WORK | 2024年 / 15卷 / 01期

关键词：

Asbestos; Meta-analysis; Ovarian cancer; PELVIC-INFLAMMATORY-DISEASE; COHORT MORTALITY; BLUE ASBESTOS; GAS MASKS; WORKERS; WOMEN; CHRYSOTILE; RISK; ADULTS; BIAS;

D O I：

10.1016/j.shaw.2023.11.002

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

Background: The International Agency for Research on Cancer (IARC) Monograph conducted a systematic review of the relationship between asbestos and ovarian cancer. However, there may have been information bias due to the undue weight given to few articles. To address this limitation, the present study performed a meta-analysis integrating studies published both before and after the 2012 IARC Monograph on Asbestos, with the aim of investigating the association between asbestos exposure and ovarian cancer. Methods: A comprehensive search of major journal databases was conducted to identify studies examining the relationship between asbestos exposure and ovarian cancer, including those featured in the 2012 IARC Monograph on Asbestos. A meta-analysis on asbestos exposure and cancer risk was performed. Results: The meta-analysis of studies published after the 2012 IARC Monograph on Asbestos found a summary Standardized Mortality Ratio (SMR) of 2.04 (95% CI: 1.03d4.05; p = 0.0123; 5 studies), with a significant degree of heterogeneity among the studies (I2 = 72.99%). The combined analysis of 15 studies before and after the 2012 IARC Monograph showed an overall summary SMR of 1.72 (95% CI: 1.43d2.06; p = 0.0349; 15 studies), with a moderate degree of heterogeneity (I2 = 42.99%). Conclusion: This meta-analysis provides evidence of a significant association between asbestos exposure and ovarian cancer mortality. While the possibility of misdiagnosis in earlier studies cannot be completely ruled out, recent findings suggest a robust correlation between asbestos exposure and ovarian cancer. This highlights the importance of sustained efforts to minimize asbestos exposure and protect public health. (c) 2024 Occupational Safety and Health Research Institute. Published by Elsevier B.V. on behalf of Institute, Occupational Safety and Health Research Institute, Korea Occupational Safety and Health Agency. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/ licenses/by-nc-nd/4.0/).

引用

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