Tertiary lymphoid structures in cancer: maturation and induction

被引：22

作者：

Chen, Yulu ^{[1
,2
,3
]}

Wu, Yuhao ^{[1
,2
,3
]}

Yan, Guorong ^{[1
,2
,3
]}

Zhang, Guolong ^{[1
,2
,3
]}

机构：

[1] Tongji Univ, Shanghai Skin Dis Hosp, Sch Med, Dept Phototherapy, Shanghai, Peoples R China

[2] Tongji Univ, Shanghai Skin Dis Hosp, Skin Canc Ctr, Sch Med, Shanghai, Peoples R China

[3] Tongji Univ, Inst Photomed, Sch Med, Shanghai, Peoples R China

来源：

FRONTIERS IN IMMUNOLOGY | 2024年 / 15卷

关键词：

tertiary lymphoid structure; immunotherapy; cancer treatment; tumor microenvironment; maturity; ANTITUMOR IMMUNITY; B-CELLS; IMMUNOTHERAPY; SURVIVAL; THERAPY; CHEMOTHERAPY; RESPONSES;

D O I：

10.3389/fimmu.2024.1369626

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Tertiary lymphoid structure (TLS) is an ectopic lymphocyte aggregate formed in peripheral non-lymphoid tissues, including inflamed or cancerous tissue. Tumor-associated TLS serves as a prominent center of antigen presentation and adaptive immune activation within the periphery, which has exhibited positive prognostic value in various cancers. In recent years, the concept of maturity regarding TLS has been proposed and mature TLS, characterized by well-developed germinal centers, exhibits a more potent tumor-suppressive capacity with stronger significance. Meanwhile, more and more evidence showed that TLS can be induced by therapeutic interventions during cancer treatments. Thus, the evaluation of TLS maturity and the therapeutic interventions that induce its formation are critical issues in current TLS research. In this review, we aim to provide a comprehensive summary of the existing classifications for TLS maturity and therapeutic strategies capable of inducing its formation in tumors.

引用

页数：13

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