The landscape of drug resistant absence seizures in adolescents and adults: Pathophysiology, electroclinical spectrum and treatment options

被引：2

作者：

Daquin, G. ^{[1
]}

Bonini, F. ^{[1
,2
,3
]}

机构：

[1] Timone Hosp, AP HM, Epileptol & Cerebral Rythmol, Marseille, France

[2] Aix Marseille Univ, Inst Neurosci Syst, INSERM, INS, Marseille, France

[3] CHU Timone, Serv epileptol & rythmol cerebrale, 264 rue St Pierre, F-13005 Marseille, France

来源：

REVUE NEUROLOGIQUE | 2024年 / 180卷 / 04期

关键词：

Absence seizures; Drug-resistance; Genetic generalized epilepsies; Idiopathic generalized epilepsies; Developmental epileptic; encephalopathies; EEG; Deep brain stimulation; IDIOPATHIC GENERALIZED EPILEPSY; LENNOX-GASTAUT SYNDROME; JUVENILE MYOCLONIC EPILEPSY; VAGUS NERVE-STIMULATION; PAROXYSMAL FAST ACTIVITY; EYELID MYOCLONIA; SPIKE-WAVE; IMPAIRED CONSCIOUSNESS; 15Q13.3; MICRODELETIONS; ANTIEPILEPTIC DRUGS;

D O I：

10.1016/j.neurol.2023.11.010

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

The persistence of typical absence seizures (AS) in adolescence and adulthood may reduce the quality of life of patients with genetic generalized epilepsies (GGEs). The prevalence of drug resistant AS is probably underestimated in this patient population, and treatment options are relatively scarce. Similarly, atypical absence seizures in developmental and epileptic encephalopathies (DEEs) may be unrecognized, and often persist into adulthood despite improvement of more severe seizures. These two seemingly distant conditions, represented by typical AS in GGE and atypical AS in DEE, share at least partially overlapping pathophysiological and genetic mechanisms, which may be the target of drug and neurostimulation therapies. In addition, some patients with drug-resistant typical AS may present electroclinical features that lie in between the two extremes represented by these generalized forms of epilepsy. # 2024 Elsevier Masson SAS. All rights reserved.

引用

页码：256 / 270

页数：15

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