Synthesis, characterization and biological evaluation of N- substituted indolyl chalcones as anticancer, anti-inflammatory and antioxidant agents

被引：9

作者：

Chavan H.V. ^{[1
]}

Ganapure S.D. ^{[2
]}

Mali N.N. ^{[3
]}

Bhale P.S. ^{[4
]}

机构：

[1] Department of Chemistry, A.S.P. College, Devrukh, Maharashtra, Dist-Ratnagiri

[2] Department of Chemistry, Annasaheb Awate Arts, Commerce and Hutatma Babu Genu Science College, Manchar, Tal. Ambegaon, Maharashtra, Dist. Pune

[3] Department of Chemistry, Dr. Babasaheb Ambedkar, Marathwada University(Aurangabad), Sub-Campus, Maharashtra, Osmanabad

[4] Department of Chemistry, Yeshwantrao Chavan Mahavidyalaya, Tuljapur, Maharashtra, Dist-Osmanabad

来源：

Materials Today: Proceedings | 2023年 / 73卷

关键词：

Anti-cancer; Anti-inflammatory; Antioxidant activity; Chalcones; Indole;

D O I：

10.1016/j.matpr.2022.09.264

中图分类号：

学科分类号：

摘要：

A series of N- substituted indolyl chalcones were synthesized and evaluated for their anticancer, anti-inflammatory and antioxidant activity. Adequate confirmation of the synthesized compounds was achieved using modern analytical techniques like FT-IR, HRMS, 1H NMR and 13C NMR spectroscopic techniques. Eighteen compounds were tested against MCF7 breast cancer cell line and monkey normal Vero cell line and calculated GI50 values from averages of 3 experiments. Compound 3a and 3 m exhibited potent activity (GI50 = <0.1 and 16.3 µM respectively) against the MCF7 (estrogen receptor-positive) cell line which was almost as good as that of standard drug adriamycin (GI50 = <0.1 µM). Synthesized compounds were also evaluated for their antioxidant and anti-inflammatory activity. Most of the N- substituted indolyl chalcones displayed excellent antioxidant and anti-inflammatory activity. © 2022

引用

页码：396 / 402

页数：6

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