Antimicrobial properties and bonding durability of pH-responsive dentin adhesives with chlorhexidine-load mesoporous silica nanoparticles

被引:0
|
作者
Li, Sining [1 ,2 ]
Qi, Le [1 ,2 ]
Liu, Zhihui [1 ,2 ]
机构
[1] Jilin Univ, Hosp Stomatol, Changchun, Peoples R China
[2] Jilin Prov Key Lab Tooth Dev & Bone Remodeling, Changchun, Peoples R China
关键词
dentin bonding; mesoporous silica nanoparticles; chlorhexidine; pH-sensitive; drug delivery; IN-VITRO; COMPOSITE; RELEASE; FORMULATION; ENAMEL;
D O I
10.3389/fmats.2024.1379941
中图分类号
T [工业技术];
学科分类号
08 ;
摘要
In this study, we synthesized pH-sensitive CHX@SBA-PDA nanoparticles and characterized their structure. These nanoparticles were then incorporated into Single Bond 2 commercial dentin adhesive. Subsequently, timely and long-term antibacterial evaluation, cytotoxicity evaluation and bonding properties were conducted. The results demonstrated the successful synthesis of CHX@SBA-PDA nanoparticles. Moreover, CHX@SBA-PDA exhibited excellent pH sensitivity and maintained a high release rate of chlorhexidine (CHX) under cariogenic low pH conditions. At pH 5.0, the release rate could reach up to 71.1% after 24 h of incubation with CHX@SBA-PDA nanoparticles. Among the different adhesive formulations tested, the 2% wt adhesive displayed the strongest immediate and 30 days bacterial inhibition ability (p < 0.05). No significant difference was observed in immediate shear strength among the four groups (p > 0.05). After undergoing pH cycling, all functional adhesive groups exhibited higher shear strength compared to the control group (p < 0.05). Furthermore, there was no significant difference in cell proliferation activity between the experimental group and control group (p > 0.05). In conclusion, our functional dentin adhesive containing CHX@SBA-PDA nanoparticles demonstrated long-term antibacterial properties as well as improved bond strength characteristics, thus, offering a promising approach to enhance durability of bonded restorations.
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页数:13
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