GPi/GPe borderland- a potential sweet spot for deep brain stimulation for chorea in Huntington's disease?

被引：3

作者：

Steinhardt, Julia ^{[1
,2
,3
]}

Zittel, Simone ^{[4
]}

Tadic, Vera ^{[1
,2
,3
,5
]}

Tronnier, Volker ^{[6
]}

Moll, Christian ^{[4
]}

Baeumer, Tobias ^{[3
,7
]}

Muenchau, Alexander ^{[3
,7
]}

Rasche, Dirk ^{[6
]}

Brueggemann, Norbert ^{[1
,2
,3
,5
]}

机构：

[1] Univ Lubeck, Dept Neurol, Ratzeburger Allee 160, D-23538 Lubeck, Germany

[2] Univ Lubeck, Inst Neurogenet, Ratzeburger Allee 160, D-23538 Lubeck, Germany

[3] Univ Lubeck, Ctr Brain Behav & Metab, Lubeck, Germany

[4] Univ Med Ctr Hamburg Eppendorf, Dept Neurol, Hamburg, Germany

[5] Univ Lubeck, Inst Neurogenet, Lubeck, Germany

[6] Univ Lubeck, Dept Neurosurg, Lubeck, Germany

[7] Univ Lubeck, Inst Syst Motor Sci, Lubeck, Germany

来源：

NEUROLOGICAL RESEARCH AND PRACTICE | 2024年 / 6卷 / 01期

关键词：

Huntington's disease; Deep brain stimulation; Chorea; Volume of tissue activated; Globus pallidus externus;

D O I：

10.1186/s42466-024-00316-5

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Background Pallidal deep brain stimulation (GPi-DBS) has been considered as an effective treatment option for medication-refractory Huntington's disease (HD). Objectives To identify stimulation-dependent effects on motor symptoms and to determine if these alterations are associated with the local impact of DBS on different pallidal parcellations. Methods We prospectively evaluated the effects of bilateral GPi-DBS within one year in 5 HD patients. We evaluated the effects of GPi-DBS on choreatic symptoms and UHDRS. Electrode placement in the pallidum was localized, and the local impact of DBS was estimated. Results The chorea subscore (p < 0.001) and UHDRS total motor score was significantly reduced postoperatively (p = 0.019). Pallidal DBS did not improve other motor symptoms. Activation of the lateral GPi/GPe was associated with improvement in choreatic symptoms (p = 0.048; r = 0.90). Conclusions Our findings indicate that stimulation of the lateral GPi has a stable effect on choreatic symptoms. The modulation of the electrical field is relevant for motor outcome.

引用

页数：3

共 10 条

[1] Behavioral and neurophysiological evidence for the enhancement of cognitive control under dorsal pallidal deep brain stimulation in Huntington's disease [J].

Beste, Christian ;

Mueckschel, Moritz ;

Elben, Saskia ;

Hartmann, Christian J. ;

McIntyre, Cameron C. ;

Saft, Carsten ;

Vesper, Jan ;

Schnitzler, Alfons ;

Wojtecki, Lars .

BRAIN STRUCTURE & FUNCTION, 2015, 220 (04) :2441-2448

[2] Probabilistic Mapping of Deep Brain Stimulation: Insights from 15 Years of Therapy [J].

Elias, Gavin J. B. ;

Boutet, Alexandre ;

Joel, Suresh E. ;

Germann, Jurgen ;

Gwun, Dave ;

Neudorfer, Clemens ;

Gramer, Robert M. ;

Algarni, Musleh ;

Paramanandam, Vijayashankar ;

Prasad, Sreeram ;

Beyn, Michelle E. ;

Horn, Andreas ;

Madhavan, Radhika ;

Ranjan, Manish ;

Lozano, Christopher S. ;

Kuhn, Andrea A. ;

Ashe, Jeff ;

Kucharczyk, Walter ;

Munhoz, Renato P. ;

Giacobbe, Peter ;

Kennedy, Sidney H. ;

Woodside, D. Blake ;

Kalia, Suneil K. ;

Fasano, Alfonso ;

Hodaie, Mojgan ;

Lozano, Andres M. .

ANNALS OF NEUROLOGY, 2021, 89 (03) :426-443

[3] Quadruple deep brain stimulation in Huntington's disease, targeting pallidum and subthalamic nucleus: case report and review of the literature [J].

Gruber, D. ;

Kuhn, A. A. ;

Schoenecker, T. ;

Kopp, U. A. ;

Kivi, A. ;

Huebl, J. ;

Lobsien, E. ;

Mueller, B. ;

Schneider, G. -H. ;

Kupsch, A. .

JOURNAL OF NEURAL TRANSMISSION, 2014, 121 (10) :1303-1312

[4] Lead-DBS: A toolbox for deep brain stimulation electrode localizations and visualizations [J].

Horn, Andreas ;

Kuehn, Andrea A. .

NEUROIMAGE, 2015, 107 :127-135

[5] External globus pallidus stimulation modulates brain connectivity in Huntington's disease [J].

Ligot, Noemie ;

Krystkowiak, Pierre ;

Simonin, Clemence ;

Goldman, Serge ;

Peigneux, Philippe ;

Van Naemen, John ;

Monclus, Michel ;

Lacroix, Simon Frederic ;

Devos, David ;

Dujardin, Kathy ;

Delmaire, Christine ;

Bardinet, Eric ;

Delval, Arnaud ;

Delliaux, Marie ;

Defebvre, Luc ;

Yelnik, Jerome ;

Blond, Serge ;

Destee, Alain ;

De Tiege, Xavier .

JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM, 2011, 31 (01) :41-46

[6] Motor and cognitive improvement by deep brain stimulation in a transgenic rat model of Huntington's disease [J].

Temel, Yasin ;

Cao, Chunyan ;

Vlamings, Rinske ;

Blokland, Arjan ;

Ozen, Hatice ;

Steinbusch, Harry W. M. ;

Michelsen, Kimmo A. ;

von Horsten, Stephan ;

Schmitz, Christoph ;

Visser-Vandewalle, Veerle .

NEUROSCIENCE LETTERS, 2006, 406 (1-2) :138-141

[7] Post-mortem Findings in Huntington's Deep Brain Stimulation: A Moving Target Due to Atrophy [J].

Vedam-Mai, Vinata ;

Martinez-Ramirez, Daniel ;

Hilliard, Justin D. ;

Carbunaru, Samuel ;

Yachnis, Anthony T. ;

Bloom, Joshua ;

Keeling, Peyton ;

Awe, Lisa ;

Foote, Kelly D. ;

Okun, Michael S. .

TREMOR AND OTHER HYPERKINETIC MOVEMENTS, 2016, 6

[8] Deep Brain Stimulation in Huntington's DiseasePreliminary Evidence on Pathophysiology, Efficacy and Safety [J].

Wojtecki, Lars ;

Groiss, Stefan Jun ;

Hartmann, Christian Johannes ;

Elben, Saskia ;

Omlor, Sonja ;

Schnitzler, Alfons ;

Vesper, Jan .

BRAIN SCIENCES, 2016, 6 (03)

[9] A prospective pilot trial for pallidal deep brain stimulation in Huntington's disease [J].

Wojtecki, Lars ;

Groiss, Stefan J. ;

Ferrea, Stefano ;

Elben, Saskia ;

Hartmann, Christian J. ;

Dunnett, Stephen B. ;

Rosser, Anne ;

Saft, Carsten ;

Suedmeyer, Martin ;

Ohmann, Christian ;

Schnitzler, Alfons ;

Vesper, Jan .

FRONTIERS IN NEUROLOGY, 2015, 6

[10] Prospective evaluation of Globus pallidus internus deep brain stimulation in Huntington's disease [J].

Zittel, S. ;

Tadic, V. ;

Moll, C. K. E. ;

Baeumer, T. ;

Fellbrich, A. ;

Gulberti, A. ;

Rasche, D. ;

Brueggemann, N. ;

Tronnier, V. ;

Muenchau, A. .

PARKINSONISM & RELATED DISORDERS, 2018, 51 :96-100

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