Synthesis of 7-[2-(Dimethylamino)vinyl]pyrazolo[1,5-a]pyrimidine-6-carbonitriles and Their Heterocyclizations with N1 Synthons

被引：0
作者：
Polikarchuk, V. A. [1 ]
Derkachev, M. S. [1 ]
Shikhaliev, Kh. S. [1 ]
机构：
[1] Voronezh State Univ, Voronezh 394006, Russia
来源：
RUSSIAN JOURNAL OF ORGANIC CHEMISTRY | 2024年 / 60卷 / 05期
关键词：
pyrazolo[1,5-a]pyrimidine; 3-oxobutanenitrile; heterocyclization; N1; synthon; dimethylaminovinyl derivative; annulation; pyrazolo[1,5-a]pyrido[3,4-e]pyrimidine; EFFICIENT SYNTHESIS; DERIVATIVES; ENAMINONITRILES; RING; PYRIMIDINE; REACTIVITY; PYRAZOLE; FACILE;
D O I：
10.1134/S1070428024050087
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The use of new 7-methylazolo[1,5-a]pyrimidine-6-carbonitriles for the construction of heterocyclic systems annulated at the pyrimidine ring has been demonstrated. Cascade cyclizations are carried out via the intermediate dimethylaminovinyl derivatives. The specific features of the cascade reactions with ammonia or aliphatic amines as N1 synthons, depending on the reaction conditions, are demonstrated.
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页码：852 / 861
页数：10
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