Spanlastic-laden nanogel as a plausible platform for dermal delivery of bimatoprost with superior cutaneous deposition and hair regrowth efficiency in androgenic alopecia

被引:6
作者
Almutairy, Bjad K. [1 ]
Khafagy, El-Sayed [1 ,2 ]
Aldawsari, Mohammed F. [1 ]
Alshetaili, Abdullah [1 ]
Alotaibi, Hadil Faris [3 ]
Lila, Amr Selim Abu [4 ,5 ]
机构
[1] Prince Sattam Bin Abdulaziz Univ, Coll Pharm, Dept Pharmaceut, Alkharj 11942, Saudi Arabia
[2] Suez Canal Univ, Fac Pharm, Dept Pharmaceut & Ind Pharm, Ind Pharm, Ismailia 41522, Egypt
[3] Princess Nourah Bint AbdulRahman Univ, Coll Pharm, Dept Pharmaceut Sci, POB 84428, Riyadh 11671, Saudi Arabia
[4] Zagazig Univ, Fac Pharm, Dept Pharmaceut & Ind Pharm, Zagazig 44519, Egypt
[5] Univ Hail, Coll Pharm, Dept Pharmaceut, Hail 81442, Saudi Arabia
关键词
Androgenic alopecia; Bimatoprost; Dermal delivery; Skin deposition; Spanlastics; IN-VITRO CHARACTERIZATION; TOPICAL DELIVERY; EX-VIVO; STATISTICAL OPTIMIZATION; SITU GEL; ACID; FORMULATION; MANAGEMENT; LIPOSOMES; NIOSOMES;
D O I
10.1016/j.ijpx.2024.100240
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
Bimatoprost (BIM) is a prostaglandin F2 alpha analogs originally approved for the treatment of glaucoma and ocular hypertension. Recent studies have highlighted its potential to boost hair growth. The objective of this investigation is to challenge the potential of spanlastics (SLs) as a surfactant-based vesicular system for promoting the cutaneous delivery of BIM for the management of alopecia. BIM-loaded spanlastics (BIM-SLs), composed of Span as the main vesicle component and Tween as the edge activator, were fabricated by ethanol injection method. The formulated BIM-SLs were optimized by 23 full factorial design. The optimized formula (F1) was characterized for entrapment efficiency, surface charge, vesicle size, and drug release after 12 h (Q12h). The optimized formula (F1) exhibited high drug entrapment efficiency (83.1 +/- 2.1%), appropriate zeta potential (-19.9 +/- 2.1 mV), Q12h of 71.3 +/- 5.3%, and a vesicle size of 364.2 +/- 15.8 nm, which favored their cutaneous accumulation. In addition, ex-vivo skin deposition studies revealed that entrapping BIM within spanlastic-based nanogel (BIMSLG) augmented the dermal deposition of BIM, compared to na & iuml;ve BIM gel. Furthermore, in vivo studies verified the efficacy of spanlastic vesicles to boost the cutaneous accumulation of BIM compared to naive BIM gel; the AUC0-12h of BIM-SLG was 888.05 +/- 72.31 mu g/mL.h, which was twice as high as that of na & iuml;ve BIM gel (AUC0-12h 382.86 +/- 41.12 mu g/mL.h). Intriguingly, BIM-SLG outperforms both na & iuml;ve BIM gel and commercial minoxidil formulations in stimulating hair regrowth in an androgenetic alopecia mouse model. Collectively, spanlastic vesicles might be a potential platform for promoting the dermal delivery of BIM in managing alopecia.
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页数:10
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