A brief overview of drug-induced liver damage

被引：0

作者：

Roy, Soumyadip ^{[1
]}

Shah, Zalak ^{[1
]}

Chakraborthy, G. S. ^{[1
]}

机构：

[1] Parul Univ, Parul Inst Pharm & Res, Dept Pharmacol, Vadodara, Gujarat, India

来源：

EGYPTIAN JOURNAL OF INTERNAL MEDICINE | 2024年 / 36卷 / 01期

关键词：

Liver injury; Drug; Hypersensitivity; Toxicity; Serum biomarkers; INDUCED HEPATOTOXICITY; ORAL MEDICATIONS; HEPATITIS-B; CELL-DEATH; INJURY; KERATIN-18; BIOMARKERS; FAILURE; RISK; MECHANISMS;

D O I：

10.1186/s43162-024-00315-7

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Drug-induced liver injury (DILI) is a prevalent disorder that can be led on by almost all drug types. The majority of benign DILI cases become better after drug discontinuation. To stop the development of acute or chronic liver failure, it is crucial to identify and get rid of the offending substance as soon as feasible. DILI does not have any identified risk factors, but certain people may be more susceptible due to genetic vulnerability and previous liver disease. Some patients may exhibit indications of systemic hypersensitivity, even though the majority of patients have clinical symptoms that are the same as those of other liver illnesses. Rapid drug withdrawal and supportive care aimed at reducing uncomfortable symptoms comprise the treatment for drug- and herbal-induced liver damage.

引用

页数：8

共 58 条

[1] Chemotherapy-induced sclerosing cholangitis: Long-term response to endoscopic therapy [J].

Alazmi, WM ;

McHenry, L ;

Watkins, JL ;

Fogel, EL ;

Schmidt, S ;

Sherman, S ;

Lehman, GL .

JOURNAL OF CLINICAL GASTROENTEROLOGY, 2006, 40 (04) :353-357

[2]

[Anonymous], 2020, Drug-induced liver injury (DILI): current status and future directions for drug development and the post-market setting. A consensus by a CIOMS Working Group

[3]

Antoine DJ, 2008, EXPERT OPIN DRUG MET, V4, P1415, DOI [10.1517/17425255.4.11.1415, 10.1517/17425255.4.11.1415 ]

[4] Mechanistic biomarkers provide early and sensitive detection of acetaminophen-induced acute liver injury at first presentation to hospital [J].

Antoine, Daniel J. ;

Dear, James W. ;

Lewis, Philip Starkey ;

Platt, Vivien ;

Coyle, Judy ;

Masson, Moyra ;

Thanacoody, Ruben H. ;

Gray, Alasdair J. ;

Webb, David J. ;

Moggs, Jonathan G. ;

Bateman, D. Nicholas ;

Goldring, Christopher E. ;

Park, B. Kevin .

HEPATOLOGY, 2013, 58 (02) :777-787

[5] RETRACTED: Molecular forms of HMGB1 and keratin-18 as mechanistic biomarkers for mode of cell death and prognosis during clinical acetaminophen hepatotoxicity (Publication with Expression of Concern. See vol. 73, pg. 1297, 2020) (Publication with Expression of Concern. See vol. 69, pg. 1402, 2018) (Retracted article. See vol. 73, pg. 1297, 2020) [J].

Antoine, Daniel J. ;

Jenkins, Rosalind E. ;

Dear, James W. ;

Williams, Dominic P. ;

McGill, Mitchell R. ;

Sharpe, Matthew R. ;

Craig, Darren G. ;

Simpson, Kenneth J. ;

Jaeschke, Hartmut ;

Park, B. Kevin .

JOURNAL OF HEPATOLOGY, 2012, 56 (05) :1070-1079

[6] High-Mobility Group Box-1 Protein and Keratin-18, Circulating Serum Proteins Informative of Acetaminophen-Induced Necrosis and Apoptosis In Vivo [J].

Antoine, Daniel J. ;

Williams, Dominic P. ;

Kipar, Anja ;

Jenkins, Rosalind E. ;

Regan, Sophie L. ;

Sathish, Jean G. ;

Kitteringham, Neil R. ;

Park, B. Kevin .

TOXICOLOGICAL SCIENCES, 2009, 112 (02) :521-531

[7] Biomarkers and surrogate endpoints: Preferred definitions and conceptual framework [J].

Atkinson, AJ ;

Colburn, WA ;

DeGruttola, VG ;

DeMets, DL ;

Downing, GJ ;

Hoth, DF ;

Oates, JA ;

Peck, CC ;

Schooley, RT ;

Spilker, BA ;

Woodcock, J ;

Zeger, SL .

CLINICAL PHARMACOLOGY & THERAPEUTICS, 2001, 69 (03) :89-95

[8] Uncoupling of rat and human mitochondria: A possible explanation for tacrine-induced liver dysfunction [J].

Berson, A ;

Renault, S ;

Letteron, P ;

Robin, MA ;

Fromenty, B ;

Fau, D ;

LeBot, MA ;

Riche, C ;

DurandSchneider, AM ;

Feldmann, G ;

Pessayre, D .

GASTROENTEROLOGY, 1996, 110 (06) :1878-1890

[9] Incidence and risk factors for non-alcoholic steatohepatitis: prospective study of 5408 women enrolled in Italian tamoxifen chemoprevention trial [J].

Bruno, S ;

Maisonneuve, P ;

Castellana, P ;

Rotmensz, N ;

Rossi, S ;

Maggioni, M ;

Persico, M ;

Colombo, A ;

Monasterolo, F ;

Casadei-Giunchi, D ;

Desiderio, F ;

Stroffolini, T ;

Sacchini, V ;

Decensi, A ;

Veronesi, U .

BMJ-BRITISH MEDICAL JOURNAL, 2005, 330 (7497) :932-935

[10]

Chitturi S, 2001, Semin Gastrointest Dis, V12, P113

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