Pectin hydrogels for controlled drug release: Recent developments and future prospects

被引:19
作者
Kapoor, Devesh U. [1 ]
Garg, Rahul [2 ]
Gaur, Mansi [3 ]
Pareek, Ashutosh [4 ]
Prajapati, Bhupendra G. [5 ]
Castro, Guillermo R. [6 ]
Suttiruengwong, Supakij [7 ]
Sriamornsak, Pornsak [8 ,9 ,10 ]
机构
[1] Dr Dayaram Patel Pharm Coll, Bardoli 394601, Gujarat, India
[2] Asian Coll Pharm, Dept Pharm, Udaipur 313001, Rajasthan, India
[3] Rajasthan Univ Hlth Sci, Rajasthan Pharm Coll, Jaipur 302020, India
[4] Banasthali Vidyapith, Dept Pharm, Banasthali 304022, Rajasthan, India
[5] Ganpat Univ, Sree SK Patel Coll Pharmaceut Educ & Res, Dept Pharmaceut & Pharmaceut Technol, Mehsana 384012, Gujarat, India
[6] Fed Univ ABC, Ctr Nat & Human Sci, Nanomed Res Unit, BR-09210580 Santo Andre, SP, Brazil
[7] Silpakorn Univ, Fac Engn & Ind Technol, Dept Mat Sci & Engn, Nakhon Pathom 73000, Thailand
[8] Silpakorn Univ, Fac Pharm, Dept Ind Pharm, Nakhon Pathom 73000, Thailand
[9] Royal Soc Thailand, Acad Sci, Bangkok 10300, Thailand
[10] Saveetha Univ, Saveetha Inst Med & Tech Sci, Saveetha Med Coll & Hosp, Ctr Global Hlth Res, Chennai 602105, Tamil Nadu, India
关键词
Controlled release; Crosslinking; Hydrogels; Oral drug delivery; Pectin; Transdermal delivery; CONTROLLED DELIVERY; SUSTAINED-RELEASE; ENCAPSULATION; STABILITY; EMULSIONS; BEHAVIOR; ORDER;
D O I
10.1016/j.jsps.2024.102002
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
Pectin hydrogels have emerged as a highly promising medium for the controlled release of pharmaceuticals in the dynamic field of drug delivery. The present review sheds light on the broad range of applications and potential of pectin-based hydrogels in pharmaceutical formulations. Pectin, as a biopolymer, is a versatile candidate for various drug delivery systems because of its wide range of properties and characteristics. The information provided on formulation strategies and crosslinking techniques provides researchers with tools to improve drug entrapment and controlled release. Furthermore, this review provides a more in-depth understanding of the complex factors influencing drug release from pectin hydrogels, such as the impact of environmental conditions and drug-specific characteristics. Pectin hydrogels demonstrate adaptability across diverse domains, ranging from applications in oral and transdermal drug delivery to contributions in wound healing, tissue engineering, and ongoing clinical trials. While standardization and regulatory compliance remain significant challenges, the future of pectin hydrogels appears to be bright, opening up new possibilities for advanced drug delivery systems.
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页数:16
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